This is the second edition of a well received book that reviews classical epidemiological and clinical research designs, with a specific focus on aging. Chapters cover basic topics like the scientific method, ethics, and the consequences of certain exclusion criteria. The work also includes a look at clinical concepts like multimorbidity, frailty and functionality. New material includes chapters such as geroscience, health systems research, big data and data mining, financing and future of aging research. The authors reveal the issues and challenges for researchers of age and aging, and also consider, from basic to clinical, and from clinical to public policies of social and health care. The focus on aging is what gives this book its valuable perspective on research methodology. All authors have considerable experience in aging, geriatrics or gerontology, and each chapter includes both a theoretical framework and practical examples of studies in aging. Readers will discover study designs that are reviewed for basic structure, main flaws and advantages, and are analyzed for specific conditions and variables regarding aging. This text is suited to both health care professionals caring for older adults, and researchers who are new to research in aging. It is relevant across the disciplines, including medicine, psychology, social sciences and dentistry, and it supports learning with graphs and figures. Front Matter ....Pages i-xii The Need for Differentiated Research Methodology in Aging (Mario Ulises Pérez-Zepeda, Carmen García-Peña, Luis Miguel Gutiérrez-Robledo)....Pages 1-9 The Scientific Method as a Point of Departure in Aging Research (Rubén Fossion, Leonardo Zapata-Fonseca)....Pages 11-24 Biomedical Research in Aging (José Mario González-Meljem, Scott Haston, Suchira Gallage, Andrew J. Innes)....Pages 25-54 Geroscience (Isabel Arrieta-Cruz, Armando Luna-López)....Pages 55-62 Descriptive Studies in Clinical Gerontology and Geriatrics (Mario Ulises Pérez-Zepeda, Lorena Jocabed Rocha Balcázar, Miguel Germán Borda)....Pages 63-72 Qualitative Research in Gerontology and Geriatrics (Fernando A. Wagner, Laurens G. Van Sluytman, Halaevalu F. Ofahengaue Vakalahi, Chioma Nwakanma Wosu)....Pages 73-81 Case-Control Studies in Aging Research (Sergio Sánchez-García, Erika Heredia-Ponce, Luis Pablo Cruz-Hervert, Ángel Cárdenas-Bahena, Laura Bárbara Velázquez-Olmedo, Carmen García-Peña)....Pages 83-93 Longitudinal Studies and Older Adults Cohorts (Carmen García-Peña, Claudia Espinel-Bermúdez, Pamela Tella-Vega, Mario Ulises Pérez-Zepeda, Luis Miguel Gutiérrez-Robledo)....Pages 95-113 Clinical Trials on Aging Research (Mario Ulises Pérez-Zepeda, Antonio Cherubini, Carmen García-Peña, Elisa Zengarini, Luis Miguel Gutiérrez-Robledo)....Pages 115-127 Mixed Methods in Geriatrics and Gerontology Research (Joseph J. Gallo, Jin Hui Joo)....Pages 129-142 Systematic Reviews and Meta-Analysis in Aging Research (Miguel Ángel Villasís-Keever, Mario Enrique Rendón-Macías, Raúl Hernán Medina-Campos)....Pages 143-155 Health Systems Research in Aging (Hortensia Reyes-Morales, Svetlana V. Doubova, Ricardo Pérez-Cuevas)....Pages 157-174 Technology and Aging: Ubiquitous Sensing Technology for Aging Research (Jesús Favela, Luis A. Castro)....Pages 175-184 The Challenge of Big Data and Data Mining in Aging Research (Juan Carlos Gómez-Verján, Luis Miguel Gutiérrez-Robledo)....Pages 185-196 Research in Public Policies for Aging (Elizabeth Caro-López, Ernesto Velasco-Sánchez)....Pages 197-208 Ethical Issues in Research in Aging (Tirso Zúñiga-Santamaría, Carmen Jimena Vázquez-García)....Pages 209-219 Integration of Consortiums and Search for International Funding (David X. Marquez, Iraida V. Carrion, Susan Aguiñaga, Melissa Lamar)....Pages 221-229 Future of Aging Research (Matteo Cesari, Marco Canevelli, Mario Ulises Pérez-Zepeda)....Pages 231-241 Back Matter ....Pages 243-246