Biochemistry

Preface Biochemistry......Page 1 Part 1......Page 11 01 Protein Flexibility and Coiled-Coil Propensity: New Insights Into Type III and Other Bacterial Secretion Systems ......Page 13 02 Peptides and Peptidomimetics as Tools to Probe Protein-Protein Interactions – Disruption of HIV-1 gp41 Fusion Core and Fusion Inhibitor Design ......Page 49 03 Profilin, and Vascular Diseases ......Page 75 04 E. coli Alpha Hemolysin and Properties ......Page 117 05 Human ERα and ERβ Splice Variants: Understanding Their Domain Structure in Relation to Their Biological Roles in Breast Cancer Cell Proliferation ......Page 151 06 GPCRs and G Protein Activation ......Page 171 07 Application of Quantitative Immunogold Electron Microscopy to Determine the Distribution and Relative Expression of Homo- and Heteromeric Purinergic Adenosine A1 and P2Y Receptors ......Page 199 Part 2......Page 213 08 Carbonic Anhydrase and Heavy Metals ......Page 215 09 Enzymology of Bacterial Lysine Biosynthesis ......Page 235 10 Enzyme-Mediated Preparation of Flavonoid Esters and Their Applications ......Page 273 Part 3......Page 297 11 Glucose Metabolism and Cancer......Page 299 12 HIV-1 Selectively Integrates Into Host DNA In Vitro......Page 315 13 Distinct Role for ARNT/HIF-1β in Pancreatic Beta-Cell Function, Insulin Secretion and Type 2 Diabetes ......Page 331 14 Modulation of EAAC1-Mediated Glutamate Uptake by Addicsin......Page 351 15 Functional Genomics of Anoxygenic Green Bacteria Chloroflexi Species and Evolution of Photosynthesis ......Page 375 16 Mechanism of Cargo Recognition During Selective Autophagy ......Page 391 Part 4......Page 407 17 Role of Ceramide 1-Phosphate in the Regulation of Cell Survival and Inflammation ......Page 409 18 Cholesterol: Biosynthesis, Functional Diversity, Homeostasis and Regulation by Natural Products ......Page 429 19 Stobadine – An Indole Type Alternative to the Phenolic Antioxidant Reference Trolox ......Page 453 Over the recent years, biochemistry has become responsible for explaining living processes such that many scientists in the life sciences from agronomy to medicine are engaged in biochemical research. This book contains an overview focusing on the research area of proteins, enzymes, cellular mechanisms and chemical compounds used in relevant approaches. The book deals with basic issues and some of the recent developments in biochemistry. Particular emphasis is devoted to both theoretical and experimental aspect of modern biochemistry. The primary target audience for the book includes students, researchers, biologists, chemists, chemical engineers and professionals who are interested in biochemistry, molecular biology and associated areas. The book is written by international scientists with expertise in protein biochemistry, enzymology, molecular biology and genetics many of which are active in biochemical and biomedical research. We hope that the book will enhance the knowledge of scientists in the complexities of some biochemical approaches; it will stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications of biochemistry