Biomaterials Science and Engineering

This book is written for those who would like to advance their knowledge beyond an introductory level of biomaterials or materials science and engineering. This requires one to understand more fully the science of materials, which is, of course, the foundation of biomaterials. The subject matter of this book may be divided into three parts: (1) fundamental structure-property relationships of man-made materials (Chapters 2-5) and natural biological materials, including biocompatibility (Chapters 6 and 7); (2) metallic, ceramic, and polymeric implant materials (Chapters 8-10); and (3) actual prostheses (Chapters 11 and 12). This manuscript was initially organized at Clemson University as classnotes for an introductory graduate course on biomaterials. Since then it has been revised and corrected many times based on experience with graduate students at Clemson and at Tulane University, where I taught for two years, 1981-1983, before joining the University of Iowa. I would like to thank the many people who helped me to finish this book; my son Y oon Ho, who typed all of the manuscript into the Apple Pie word processor; my former graduate students, M. Ackley Loony, W. Barb, D. N. Bingham, D. R. Clarke, J. P. Davies, M. F. DeMane, B. J. Kelly, K. W. Markgraf, N. N. Salman, W. J. Whatley, and S. o. Young; and my colleagues, Drs. W. Cooke, D. D. Moyle (Clemson G. H. Kenner (University of Utah), F. University), W. C. Van Buskirk (Tulane University), and Y. Front Matter....Pages i-xv Introduction....Pages 1-10 Characterization of Materials....Pages 11-38 Structure of Solids....Pages 39-58 Thermodynamics of Structural Changes....Pages 59-84 Strength and Strengthening Mechanisms....Pages 85-117 Structure-Property Relationships of Biological Materials....Pages 119-169 Tissue Response to Implants (Biocompatibility)....Pages 171-192 Metallic Implant Materials....Pages 193-233 Ceramic Implant Materials....Pages 235-263 Polymeric Implant Materials....Pages 265-303 Soft Tissue Replacement Implants....Pages 305-355 Hard Tissue Replacement Implants....Pages 357-419 Back Matter....Pages 421-459