Bleomycin Chemotherapy

Bleomycin Chemotherapy focuses on the clinical uses of bleomycin. Bleomycin, a group of glycopeptides isolated from Streptomyces verticillus, has a unique structure and mechanism of action among anticancer drugs. The drug's remarkable lack of bone marrow toxicity prompted its addition to myelosuppressive regimens and enabled treatment of patients with compromised hematopoietic function. Bleomycin is an integral component of one of the great triumphs of medical oncology—the curative treatment of metastatic testicular carcinomas. Similar curative potential has been demonstrated for bleomycin in combination with cisplatin and vinblastine in germ-cell cancers of the ovary. Bleomycin is included in several important treatment regimens for Hodgkin's disease and non-Hodgkin's lymphomas. The drug also has clinical activity against squamous carcinomas of various sites. These uses and other aspects, including the development of new bleomycin analogs, are discussed in the following chapters, which were first presented at a symposium jointly sponsored by the Northern California Cancer Program and Bristol Laboratories in San Francisco, California, 14-15 September 1984. Content: Front Matter , Page iii Copyright , Page iv CONTRIBUTORS , Pages xiii-xvii PREFACE , Page xix Chapter 1 - BLEOMYCIN: MORE THAN A DECADE LATER , Pages 3-35 , Stephen K. Carter Chapter 2 - CLINICAL PHARMACOLOGY OF BLEOMYCIN , Pages 37-43 , Branimir Ivan Sikic Chapter 3 - CHEMOTHERAPY OF TESTICULAR CARCINOMA: AN OVERVIEW , Pages 47-58 , Brian J. Lewis Chapter 4 - THE MEMORIAL HOSPITAL EXPERIENCE IN THE MANAGEMENT OF TESTICULAR GERM-CELL TUMORS , Pages 59-68 , Robert B. Golbey Chapter 5 - EFFECTIVE TREATMENT OF MALIGNANT OVARIAN GERM-CELL TUMORS WITH CISPLATIN, VINBLASTINE, AND BLEOMYCIN (PVB) , Pages 69-76 , Robert W. Carlson, Branimir Ivan Sikic Chapter 6 - THE ROLE OF CHEMOTHERAPY IN THE TREATMENT OF HEAD AND NECK CANCER , Pages 79-93 , Charlotte D. Jacobs Chapter 7 - HEAD AND NECK CANCER: BLEOMYCIN PLUS RADIOTHERAPY , Pages 95-107 , Karen K. Fu Chapter 8 - THE ROLE OF INDUCTION CHEMOTHERAPY IN COMBINED-MODALITY TREATMENT PROGRAMS , Pages 109-115 , Robert E. Wittes Chapter 9 - INDUCTION CHEMOTHERAPY IN THE TREATMENT OF HEAD AND NECK CANCER: SUNY BUFFALO AND VAMC EXPERIENCE , Pages 117-124 , Monica B. Spaulding Chapter 10 - HODGKIN'S DISEASE: AN OVERVIEW AND ABVD STUDIES IN MILAN , Pages 127-135 , Valeria Bonfante, Armando Santoro, Emilio Bajetta, Pinuccia Valagussa, Simonetta Viviani, Roberto Buzzoni, Gianni Bonadonna Chapter 11 - BLEOMYCIN IN COMBINATION WITH MOPP IN THE MANAGEMENT OF ADVANCED HODGKIN'S DISEASE: A SOUTHWEST ONCOLOGY GROUP EXPERIENCE , Pages 137-153 , Charles A. Coltman Jr., Petre N. Grozea, Stephen E. Jones, Edward J. De Persio, Dennis O. Dixon Chapter 12 - COMBINED-MODALITY STUDIES IN THE TREATMENT OF HODGKIN'S DISEASE , Pages 155-168 , Richard T. Hoppe Chapter 13 - THE NON-HODGKIN'S LYMPHOMAS: AN OVERVIEW , Pages 169-179 , Sandra J. Horning Chapter 14 - NON-HODGKIN'S LYMPHOMAS: MILAN STUDIES , Pages 181-186 , Valeria Bonfante, Armando Santoro, Emilio Bajetta, Pinuccia Valagussa, Simonetta Viviani, Roberto Buzzoni, Gianni Bonadonna Chapter 15 - BACOP AND RELATED STUDIES IN NON-HODGKIN'S LYMPHOMA , Pages 187-199 , Arthur T. Skarin, George P. Canellos Chapter 16 - A REASSESSMENT OF BLEOMYCIN IN LUNG CANCER AND OTHER INTRATHORACIC NEOPLASMS , Pages 203-214 , Franco M. Muggia, Daniel D. Von Hoff Chapter 17 - NON-SMALL-CELL LUNG CANCER: BLEOMYCIN PLUS ETOPOSIDE AND CISPLATIN , Pages 215-224 , David Osoba, James J. Rusthoven, Kathryn Turnbull, Ida Ackerman, Martin P. Berry, Pamela A. Catton, Geoffrey M. Davies, Hensley A.B. Miller, Glen A. Taylor, Peter M. Webster, William K. Evans, Frances A. Shepherd, Martin E. Blackstein, Martin Levitt Chapter 18 - CERVICAL CANCER: BLEOMYCIN STUDIES—AN OVERVIEW , Pages 227-238 , David S. Alberts, Silvio Aristizabal, Sheldon Weiner, Earl A. Surwit Chapter 19 - BLEOMYCIN IN CERVICAL CARCINOMA: PROTOCOLS OF THE NORTHERN CALIFORNIA ONCOLOGY GROUP , Pages 239-244 , Samuel C. Ballon, Branimir Ivan Sikic Chapter 20 - PULMONARY TOXICITY OF BLEOMYCIN , Pages 247-254 , Branimir Ivan Sikic Chapter 21 - BLEOMYCIN: THE SEARCH FOR OTHER INDICATIONS , Pages 257-273 , Arthur C. Louie Chapter 22 - PEPLOMYCIN AND TALLYSOMYCIN S 10 b: TWO BLEOMYCIN ANALOGS , Pages 277-287 , Arthur C. Louie, Robert C. Gaver, Marcel Rozencweig, Raymond H. Farmen, Robert L. Comis, C.R. Franks Chapter 23 - NEW ANALOGS AND DERIVATIVES OF BLEOMYCIN , Pages 289-301 , Hamao Umezawa, Tomohisa Takita, Sei-ichi Saito, Yasuhiko Muraoka, Katsutoshi Takahashi, Hisao Ekimoto, Seiki Minamide, Kiyohiro Nishikawa, Takeyo Fukuoka, Tokuji Nakatani, Akio Fujii, Akira Matsuda Chapter 24 - BLEOMYCIN: FUTURE PROSPECTS , Pages 305-311 , Robert E. Wittes Chapter 25 - BLEOMYCIN IN CHEMOTHERAPY: SUMMARY AND CLOSING REMARKS , Pages 313-316 , Edwin C. Cadman Edited By Branimir Ivan Sikic, Marcel Rozencweig, Stephen K. Carter. Based On A Symposium Held In San Francisco On Sept. 14 And 15, 1984, Sponsored By The Northern California Cancer Program And Bristol Laboratories. Includes Bibliographies.