Brain Metastasis

Of those people dying with cancer, many die as a result of metastases. In spite of this, a surprisingly small number of texts have been devoted to this clinically important topic. The present series of monographs originated in discussions, which convinced us of the need for texts on metasasis which would contain not only basic and clinical observations on human beings and where neces­ sary, on experimental animals but also discussions of the state of the art in diagnosis and therapy. In order to achieve this in-depth approach, for which publication was preceded by small workshops, it was necessary to impose limitations on the scope of the topic. Metastasis is therefore dis­ cussed by site, and the series is organized accordingly. The first volume in the series, Pulmonary Metastasis, was an expanded version of a Workshop held at Roswell Park Memorial Institute in 1977. This, the second volume, is based on a similar workshop on metastasis to the brain, held at the Memorial Sloan-Kettering Cancer Center in September, 1978. In organiz­ ing both the workshop and in editing this volume, we have been excep­ tionally fortunate to receive the generous cooperation of Dr. Jerome B. Posner, a practicing neurologic oncologist who has given freely of his ex­ pertise in this specialized field. Front Matter....Pages i-xxxi Front Matter....Pages 1-1 Brain Metastases....Pages 2-29 The Cell Periphery and Metastasis....Pages 30-49 Experimental Brain Metastasis....Pages 50-65 The Role of Brain Metastases in Cascade Processes: Implications for Research and Clinical Management....Pages 66-80 Arrest and Extravasation of Cancer Cells with Special Reference to Brain Metastases and the Microinjury Hypothesis....Pages 81-99 Quantitative Aspects of Osmotic Opening of the Blood-Brain Barrier....Pages 100-114 Brain Tumor Microvasculature....Pages 115-133 A Model for Brain Metastasis....Pages 134-145 Pharmacokinetics and Metastatic Brain Tumor Chemotherapy....Pages 146-164 Human Cancer Immunology....Pages 165-185 Front Matter....Pages 187-187 Clinical Manifestations of Brain Metastasis....Pages 189-207 Computed Tomography of Metastatic Disease of the Brain....Pages 208-241 Radionuclide Imaging of Cancer Metastases in the Brain....Pages 242-245 Positron-Emission Tomography....Pages 246-253 Front Matter....Pages 255-255 Analysis of the Benefit of Palliation of Brain Metastases....Pages 257-264 The Memorial Hospital Experience....Pages 265-268 The Hahnemann Experience....Pages 269-278 RTOG Experience and New Concepts....Pages 279-285 The Princess Margaret and Ontario Cancer Foundation Experience....Pages 286-302 The Southern California Permanente Medical Group Experience: Functional Results....Pages 303-313 Front Matter....Pages 255-255 Clinical Effects of Radiation on the Adult Nervous System....Pages 314-327 Chemotherapy of Metastatic Central Nervous System Carcinoma....Pages 328-339 Adrenocorticosteroid Hormones....Pages 340-363 Combined Chemotherapy and Irradiation in the Treatment of Brain Metastases from Lung Cancer....Pages 364-379 Surgical Therapy of Brain Metastases....Pages 380-389 Treatment of Brain Metastases by Surgical Extirpation....Pages 390-414 Back Matter....Pages 415-438