Brain Tumors in Children

This book is a comprehensive and up-to-date compendium of all aspects of brain tumors in children. After introductory chapters on the epidemiology of brain tumors, the book will provide readers with state-of-the art chapters on the principals of radiation therapy, neurosurgery and neuroimaging. Subsequent chapters discuss the biology and treatment of specific types of brain tumors. The concluding chapters present critical information relevant to survivorship, neurocognitive and other late effects, and the global challenges to better diagnosis and treatment of brain tumors in children. This book is co-authored by experts in the treatment of pediatric brain tumors. All of the authors are internationally recognized authorities and they offer an evidence-based consensus on the biology and treatment of brain tumors. This handbook has far-reaching applicability to the clinical diagnosis and management of brain tumors in children and will prove valuable to specialists, generalists and trainees alike. Front Matter ....Pages i-viii Epidemiology of Pediatric Central Nervous System Tumors (Nicholas A. Vitanza, Cynthia J. Campen, Paul G. Fisher)....Pages 1-15 Principles of Pediatric Neurosurgery (P. Ryan Lingo, Asim F. Choudhri, Paul Klimo Jr)....Pages 17-31 Principles of Radiation Oncology (Shannon M. MacDonald, Ranjit S. Bindra, Roshan Sethi, Matthew Ladra)....Pages 33-64 Imaging Children with CNS Tumors (Julie H. Harreld)....Pages 65-90 Predisposition Syndromes to Central Nervous System Cancers (Alberto Broniscer, Kim Nichols)....Pages 91-116 Modern Principles of CNS Tumor Classification (Stefan M. Pfister, David Capper, David T. W. Jones)....Pages 117-129 Medulloblastoma (Nicholas G. Gottardo, Christopher I. Howell)....Pages 131-175 Ependymoma (Hendrik Witt, Kristian W. Pajtler)....Pages 177-192 High-Grade Glioma, Including Diffuse Intrinsic Pontine Glioma (Matthias A. Karajannis, Matija Snuderl, Brian K. Yeh, Michael F. Walsh, Rajan Jain, Nikhil A. Sahasrabudhe et al.)....Pages 193-221 Low-Grade Gliomas (Anna K. Paulsson, Michael A. Garcia, David A. Solomon, Daphne A. Haas-Kogan)....Pages 223-250 Germ Cell Tumors (Kee Kiat Yeo, Girish Dhall)....Pages 251-264 Childhood Craniopharyngioma (Thomas E. Merchant)....Pages 265-287 Rare Embryonal Brain Tumours (Adriana Fonseca, Salma Al-Karmi, Alexandre Vasiljevic, Andrew Dodghsun, Patrick Sin Chan, Lucie Lafay Cousin et al.)....Pages 289-316 Cognitive Late Effects and Their Management (Heather M. Conklin, Jane E. Schreiber, Ashley S. Fournier-Goodnight)....Pages 317-345 Long-Term Outcomes Among Survivors of Childhood Central Nervous System Malignancies: Late Mortality, Subsequent Neoplasms, Endocrine and Neurologic Morbidity (Gregory T. Armstrong, Raja B. Khan, Wassim Chemaitilly)....Pages 347-378 Integrating Palliative Care into the Ongoing Care of Children with CNS Tumors (Justin N. Baker)....Pages 379-402 Global Challenges in Pediatric Neuro-Oncology (Simon Bailey, Jeannette Parkes, Alan Davidson)....Pages 403-426