Carbon monoxide and cardiovascular functions

Akin to nitric oxide, carbon monoxide (CO) was initially viewed as a pure toxic gas, yet it has been recently demonstrated to be an important endogenous molecule of gas that has profound physiological and pathophysiological effects on the cardiovascular system. In spite of the growing understanding achieved in this field, until now a comprehensive book summarizing the extraordinary advances in the research of the cardiovascular effects of CO has not been available. Carbon Monoxide and Cardiovascular Functions responds to the vexing challenges and exciting opportunities that confront researchers and clinicians studying the biological roles of CO in the cardiovascular system. This book presents many never-before-published results including the first case of human CO deficiency. It also discusses disorders where the cardiovascular effects of CO might have been altered, including hypertension, diabetes, stroke, and ischemic heart damage.A product of the collected knowledge of internationally respected scientists, this book serves as a standard reference summarizing recent developments, scientific controversies, and future directions in the study of the biological actions of CO on the cardiovascular system. By covering both ancient and state-of-the-art methodologies in great detail, Carbon Monoxide and Cardiovascular Functions, affords a rapid mastery of the powerful new advances in CO study. Sect. 1. Carbon Monoxide And Physiological Functions Of The Cardiovascular System. Ch. 1. The Physiological Role Of Carbon Monoxide Derived From Heme Oxidation Catalyzed By Heme Oxygenase / Gerald S. Marks, Brian E. Mclaughlin And James F. Brien / [et Al.]. Ch. 2. Carbon Monoxide-induced Vasorelaxation And The Underlying Mechanisms / Weimin Zhao And Rui Wang. Ch. 3. Carbon Monoxide And Vascular Smooth Muscle Cell Growth / William Durante. Ch. 4. Signal Transduction Pathways Involved In Co-induced Vasodilation: The Role Of Cyclic Gmp/soluble Guanylyl Cyclase / Kanji Nakatsu, James F. Brien And Brian E. Mclaughlin / [et Al.]. Ch. 5. Carbon Monoxide, Vascular Contractility, And K[superscript +] Channels / Kun Cao And Rui Wang. Ch. 6. Nitric Oxide And The Heme Oxygenase/carbon Monoxide System: Cooperation In The Control Of Vascular Function / Roberta Foresti, Colin J. Green And Roberto Motterlini. Ch. 7. Developmental Biology Of Heme Oxygenase And Carbon Monoxide In The Cardiopulmonary System / Phyllis A. Dennery. Ch. 8. Carbon Monoxide Signaling In The Heart / Dipak K. Das And Nilanjana Maulik -- Sect. 2. Carbon Monoxide And Pathophysiology Of The Cardiovascular System. Ch. 9. The Heme-heme Oxygenase-carbon Monoxide System And Hypertension / Robert A. Johnson And Fruzsina K. Johnson. Ch. 10. Carbon Monoxide And Cardiovascular Inflammation / Joseph Fomusi Ndisang, Emauela Masini And Pier Francesco Mannanoni / [et Al.]. Ch. 11. Human Ho-1 Deficiency And Cardiovascular Dysfunction / A. Yachie, A. Kawashima And K. Ohta / [et Al.]. Ch. 12. The Roles Of Carbon Monoxide In The Pathogenesis Of Diabetes And Its Vascular Complications / Lingyun Wu And Rui Wang. Ch. 13. Selective Increase In Human Heme Oxygenase-1 Gene Expression Attenuates Development Of Hypertension And Increases Body Growth In Spontaneously Hypertensive Rats / Nader G. Abraham, Shuo Quan And Sylvia Shenouda / [et Al.] -- Sect. 3. Techniques Used In Carbon Monoxide Research. Ch. 14. Studies On The Development Of Carbon Monoxide-releasing Molecules: Potential Applications For The Treatment Of Cardiovascular Dysfunction / Roberto Motterlini, Roberta Foresti And Colin J. Green. Ch. 15. Sources, Sinks, And Measurement Of Carbon Monoxide / Hendrik J. Vreman, Ronald J.wong And David K. Stevenson. Edited By Rui Wang. Includes Bibliographical References And Index. Our interest in the heme oxygenase (HO)-carbon monoxide (CO) system stems from our studies on the mechanism of action of nitroglycerin (GTN) which we have conducted for approximately 20 years.