Clinical hematology : principles, procedures, correlations

Logically organized and easy-to-understand, this invaluable second edition provides comprehensive coverage for all areas of clinical hematology. Essential information on the disorders of hematology and hemostasis and the laboratory studies used in their diagnosis and treatment are presented in a clear and efficient style. Special focus is placed on the sources of technical and physiologic error in procedures, and their possible solutions. Case studies at the end of many chapters include study questions for reinforcement of learned material. Coverage includes bone marrow evaluation, blood cell cytochemistry, body fluid evaluation, hematologic instrumentation, and quality control for hematology and hemostasis laboratories. New in this edition: Information on molecular biology, bone marrow stem cell transplantation, markers for thrombosis; and new learning aids, including chapter objectives, more case studies, chapter review questions, a glossary, and more color plates. Cover Colored Plates Table of Contents PART I: INTRODUCTION TO HEMATOLOGY Introduction To Clinical Hematology 1: Safety In The Clinical Hematology Laboratory 2: Specimen Collection 3: Specimen Preparation for Examination 4: Basic Microscopy In Hematology 5: Hematopoiesis and Review of Genetics PART II: THE ERYTHROCYTES 6: Erythropoiesis and Erythrocyte Physiology 7: Hemoglobin Synthesis and Function 8: Morphologic Examination of Erythrocytes 9: Routine Laboratory Evaluation of Erythrocytes PART III: ERYTHROCYTE ABNORMALITIES (NONMALIGNANT) 10: Introduction to Erythrocyte Abnormalities 11: Anemia of Bone Marrow Failure and Systemic Disorders 12: Anemia of Abnormal Nuclear Development 13: Anemia of Abnormal Iron Metabolism 14: Anemia of Abnormal Globin Development - Hemoglobinopathies 15: Anemias of Abnormal Globin Development - Thalassemias 16: Introduction to Anemias of Increased Erythrocyte Destruction 17: Hereditary Anemias of Increased Destruction 18: Acquired Nonimmune Anemia of Increased Destruction 19: Acquired Immune Anemia of Increased Destruction 20: Anemia of Blood Loss 21:Special Laboratory Evaluation of Erythrocyte Abnormalities PART IV: THE LEUKOCYTES 22: Introduction To The Leukocytes 23: The Phagocytic Leukocytes - Morphology, Kinetics, and Function 24: Immune Leukocytes - Maturation, Kinetics, and Function 25: Laboratory Evaluation of Leukocytes PART V: LEUKOCYTE ABNORMALITIES (NONMALIGNANT) 26: Nonmalignant, Reactive Disorders of Phagocytes 27: Nonmalignant, Reactive Disorders of Lymphocytes 28: Nonmalignant Hereditary Disorders of Leukocytes PART VI: SPECIAL HEMATOLOGIC EVALUATIONS 29: Preparation and Evaluation of Bone Marrow 30: Cytochemistry 31: Laboratory Evaluation of Body Fluids PART VII: MALIGNANT MYELOPROLIFERATIVE DISORDERS 32: Introduction to the Hematopoietic Malignancies 33: The Dysmyelopoietic Disorders 34: Acute Myeloproliferative Leukemia (Acute Nonlymphocytic Leukemia) 35: Chronic Myeloproliferative Disorders PART VIII: MALIGNANT LYMPHOPROLIFERATIVE DISORDERS 36: Acute Lymphoblastic Leukemias 37: Chronic Lymphoproliferative Leukemic Disorders 38: The Lymphomas 39: Plasma Cell Dyscrasias (Paraproteinemias) 40: Systemic Laboratory Evaluation of Leukocyte Abnormalities PART IX: INSTRUMENTATION FOR HEMATOLOGIC EVALUATION 41: Introduction to Hematologic Automation 42: Single-Parameter Parameter-Counting Instruments 43: Multiparameter Hematology Instruments 44: Instruments for Automation of the Differential 45: Flow Cytometry PART X: QC AND QA IN HEMATOLOGY 46: Introduction to QC and QA in Hematology 47: Methods to Monitor and Control Systematic Error 48: Methods to Monitor and Control Random Error PART XI: HEMOSTASIS 49: Introduction to Hemostasis 50: Mechanisms of Coagulation and Fibrinolysis 51: Specimen Collection and Processing for Hemostasis Testing 52: Routine Laboratory Evaluation of Coagulation 53: Special Laboratory Evaluation of Coagulation 54: Laboratory Evaluation of Fibrinolysis 55: Disorders of Coagulation and Fibrinolysis 56: Disorders Leading to Thrombosis 57: Laboratory Monitoring of Anticoagulant Therapy 58: The Megakaryocyte-Platelet System: Structures and Function 59: Laboratory Evaluation of Platelets 60: Quantitative Platelet Disorders 61: Qualitative Platelet Disorders 62: Instrumentation and Quality Control In Hemostasis PART XII: MANAGEMENT 63: Laboratory Management in Hematology and Hemostasis APPENDICES Answer to Case Studies Index Intended for students and practitioners in clinical laboratory science, this text stresses the physiology of blood cells, the etiologies of haematologic diseases and the theoretical basis of laboratory procedures. Clinical hematology has a relatively short history in that until the 1920s, the study of diseases related to alterations in blood cell number or appearance was a branch of clinical medicine and pathology.