Combinatorial Chemistry

The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society) Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effect Front Matter.pdf 1 Chapter 1.pdf 23 Chapter 2.pdf 54 Chapter 3.pdf 132 Chapter 4.pdf 164 Chapter 5.pdf 382 Chapter 6.pdf 477 Chapter 7.pdf 533 Chapter 8.pdf 538 Chapter 9.pdf 578 Chapter 10.pdf 633 Appendix.pdf 676 Index.pdf 680