Connexins : A Guide

"Connexins: A Guide is a practical and valuable reference and text covering a wide scope of information about the connexin family of membrane channel proteins. The editors and contributing authors intend for this cutting-edge work to be informative to scientists wishing to learn about the field, as well as to those who are active researchers in this area. Connexins: A Guide masterfully addresses specific needs of the scientific community; it is a comprehensive and comprehensible narrative of the uncommonly diverse connexin field, making previously hard-to-find information easily accessible, while also presenting intelligible insights into the extensive experimental methods and conceptual frameworks necessary to appreciate and understand the important roles that connexin channel proteins play in health and disease."--BOOK JACKET. Front Matter....Pages i-xvi Front Matter....Pages 1-1 The Family of Connexin Genes....Pages 3-26 Gap Junction Channel Structure....Pages 27-75 The Connexin Channel Pore: Pore-Lining Segments and Residues....Pages 77-102 Voltage-Gating Mechanisms of Connexin Channels....Pages 103-128 Chemical Gating of Connexin Channels....Pages 129-142 Electrical Signaling with Neuronal Gap Junctions....Pages 143-164 Permeability of Connexin Channels....Pages 165-206 Pharmacology of Connexin Channels....Pages 207-224 Biogenesis and Degradation of Gap Junctions....Pages 225-240 Gap Junction Morphology and Dynamics in Situ....Pages 241-261 Biochemistry of Connexins....Pages 263-286 Pannexins or Connexins?....Pages 287-301 Front Matter....Pages 303-303 Foreword: Gap Junctions and Emergent Organ Properties....Pages 305-306 Connexins in Skin Biology....Pages 307-321 Connexins in the Nervous System....Pages 323-357 Connexins in the Respiratory Epithelium....Pages 359-370 Connexins in Skeletal Biology....Pages 371-386 Connexins in Lens Development and Disease....Pages 387-396 Connexins in the Mammalian Retina....Pages 397-417 Connexins in the Inner Ear....Pages 419-434 Front Matter....Pages 303-303 Connexins in the Heart....Pages 435-456 Connexins in the Vasculature....Pages 457-468 Connexins and Atherosclerosis....Pages 469-479 Connexins in the Female Reproductive System....Pages 481-493 Connexins in the Male Reproductive System....Pages 495-510 Connexins and Secretion....Pages 511-527 Connexins and Carcinogenesis....Pages 529-542 Back Matter....Pages 543-573