Crash Course: Metabolism and Nutrition, 4E

The (printed) 'Updated Edition' now comes with added value access to the complete, downloadable eBook version via Student Consult. Search, read and revise whilst on the move and use the interactive self-assessment to test your understanding. Crash Course - a more flexible, practical learning package than ever before. Crash Course - your effective every day study companion PLUS the perfect antidote for exam stress! Save time and be assured you have all the information you need in one place to excel on your course and achieve exam success. A winning formula now for over 15 years, each series volume has been fine tuned and fully updated, with an improved layout tailored to make your life easier. Especially written by senior medical students or recent graduates - those who have just been in the exam situation - with all information thoroughly checked and quality assured by expert faculty advisers, the result are books which exactly meet your needs and you know you can trust. This volume explains the essential concepts of human metabolism and nutrition in a memorable, easy-to-understand format. Complex information is provided succinctly and is accompanied by a full artwork programme making an often challenging subject very accessible. A full discussion of metabolic diseases then adds relevance to the underlying concepts while clinical assessment and examination, common skills and further investigations complete the picture. A fully revised self-assessment section matching the latest exam formats is also included to check your understanding and aid exam preparation. Provides the exam syllabus in one place! Written by senior medical students or junior doctors - authors who really understand today's exam situation! Senior Faculty Advisors ensure complete accuracy of the text! Full artwork programme, improved 'Hints and Tips' boxes, and 'Clinical Application' boxes help you remember the key points! Self-Assessment section - fully updated to reflect new curriculum requirements - helps you maximise your grade! Solid, accurate, user-friendly coverage provides enough detail even for those aiming at distinction! Self-assessment section fully updated to reflect current exam requirements Contains 'common exam pitfalls' as advised by faculty Crash Courses also available electronically! Online self-assessment bank also available - content edited by Dan Horton-Szar! The (printed) 'Updated Edition' now comes with added value access to the complete, downloadable eBook version via Student Consult. Search, read and revise whilst on the move and use the interactive self-assessment to test your understanding. Crash Course - a more flexible, practical learning package than ever before. Now celebrating over 10 years of success - Crash Course has been specially devised to help you get through your exams with ease. Completely revised throughout, the new edition of Crash Course is perfectly tailored to meet your needs by providing everything you need to know in one place. Clearly presented in a tried and trusted, easy-to-use, format, each book in the series gives complete coverage of the subject in a no-nonsense, user-friendly fashion. Commencing with 'Learning Objectives', each chapter guides you succinctly through the topic, giving full coverage of the curriculum whilst avoiding unnecessary and often confusing detail. Each chapter is also supported by a full artwork programme, and features the ever popular 'Hints and Tips' boxes as well as other useful aide-mémoires. All volumes contain an up-to-date self-assessment section which allows you to test your knowledge and hone your exam skills. Authored by students or junior doctors - working under close faculty supervision - each volume has been prepared by someone who has recently been in the exam situation and so relates closely to your needs. So whether you need to get out of a fix or aim for distinction Crash Course is for you!! Content: Front Cover; Crash Course: Metabolism and Nutrition; Copyright; Series editor foreword; Prefaces; Authors; Faculty Advisor; Acknowledgements; Contents; Chapter 1: Introduction to metabolism; Introductory concepts; Metabolism; Enzymes; Enzyme nomenclature; Anabolism and catabolism; Pathway regulation; Substrate availability; Allosteric regulation; Phosphorylation; Hormonal regulation; Membrane traffic; Symports (`co-transports ́) and antiports; Active and passive transport; Primary active transport; Secondary active transport; Bioenergetics; Redox reactions; Reduction and oxidation. Free radicalsKey players; Adenosine triphosphate (ATP): Cellular `energy currency ́; Roles of ATP; Sources of ATP; NAD+ and FAD; Role of NAD+ and FAD in ATP generation; NADP+; Acetyl CoA; Chapter 2: Energy metabolism I; The tricarboxylic acid (TCA) cycle; Role in metabolism; Energy yield of the TCA cycle; Regulation of the TCA cycle; Allosteric regulation; Substrate provision/`respiratory control ́; TCA cycle intermediates as precursors; Anaplerotic reactions; TCA-generated reducing equivalents enter the electron transport system; Chapter 3: Energy metabolism II; ATP generation. Substrate-level phosphorylationOxidative phosphorylation; The electron transport chain (ETC); Electron pairs: where do they come from?; Electron pair transfer between ETC complexes; Generation of the proton gradient; Different ATP generation capacity of NADHH and FADH2; ATP synthesis; ATP synthase (complex V); The term `coupling ́; Sources of NADHH and FADH2; ETC complexes: why do they readily accept and then transfer onward incoming electron pairs?; Transfer of NADHH: from cytoplasm to the mitochondria; Glycerol-3-phosphate shuttle; Malate-aspartate shuttle; NAD+ regeneration; Uncoupling. Chapter 4: Carbohydrate metabolismCarbohydrates: A definition; Glucose entry into cells; Facilitated diffusion; Secondary active transport; Glycolysis; Overview; Glycolysis: the reaction pathway; `Energy investment ́ phase; `Energy generation ́ phase; Glycolytic intermediates as biosynthetic precursors; Regulation of glycolysis; Reaction 1: Glucose phosphorylation; Reaction 3: Fructose-6-phosphate phosphorylation; Reaction 10: Phosphoenolpyruvate pyruvate; The insulin:glucagon ratio influence on glycolysis; Aerobic glycolysis vs. anaerobic glycolysis; Hyperlactataemia. Hereditary red cell enzymopathiesThe pyruvate acetyl CoA reaction; Pyruvate dehydrogenase; Regulation of PDH; Gluconeogenesis; Necessity of a synthetic pathway for glucose; Timescale of glycogenolysis vs. gluconeogenesis; Gluconeogenesis substrates; Sequence of reactions; Key differences between gluconeogenesis and glycolysis; Regulation of gluconeogenesis; Reaction 1: Pyruvate oxaloacetate (carboxylation); Reaction 2: Oxaloacetate phosphenolpyruvate (decarboxylation); Reaction 9: Fructose-1,6-bisphosphate fructose-6-phosphate (hydrolysis); Reaction 11: Glc-6-P glucose (hydrolysis). Abstract: Helps you to get through your exams with ease. Commencing with Learning Objectives, this title guides you through the topic, providing coverage of the curriculum. Read more... The new series of Crash Course continues to provide readers with complete coverage of the MBBS curriculum in an easy-to-read, user-friendly manner. Building on the success of previous editions, the new Crash Courses retain the popular and unique features that so characterised the earlier volumes. All Crash Courses have been fully updated throughout. * Provides the exam syllabus in one place! * Written by senior medical students or junior doctors - authors **who really understand** today's exam situation! * Senior Faculty Advisors ensure complete accuracy of the text! * Full artwork programme, improved 'Hints and Tips' boxes, and 'Clinical Application' boxes help you remember the key points! * Self-Assessment section - fully updated to reflect new curriculum requirements - helps you maximise your grade! * Solid, accurate, user-friendly coverage provides enough detail even for those aiming at distinction! * Self-assessment section fully updated to reflect current exam requirements * Contains 'common exam pitfalls' as advised by faculty * Crash Courses also available electronically! * Online self-assessment bank also available - content edited by Dan Horton-Szar! Now celebrating over 10 years of success - Crash Course has been specially devised to help you get through your exams with ease. Completely revised throughout, the new edition of Crash Course is perfectly tailored to meet your needs by providing everything you need to know in one place. Clearly presented in a tried and trusted, easy-to-use, format, each book in the series gives complete coverage of the subject in a no-nonsense, user-friendly fashion. Commencing with 'Learning Objectives', each chapter guides you succinctly through the topic, giving full coverage of the curriculum whilst avoiding unnecessary and often confusing detail. Each chapter is also supported by a full artwork programme, and features the ever popular 'Hints and Tips' boxes as well as other useful aide-mémoires. All volumes contain an up-to-date self-assessment section which allows you to test your knowledge and hone your exam skills. Authored by students or junior doctors - working under close faculty supervision - each volume has been prepared by someone who has recently been in the exam situation and so relates closely to your needs. So whether you need to get out of a fix or aim for distinction __Crash Course__ is for you!! The contents of this book cover energy metabolism, carbohydrate metabolism, lipid transport and metabolism, protein metabolism, glucose homeostasis, vitamins and vitamin deficiencies, minerals and trace elements, and much more. Now celebrating over 10 years of success - Crash Course has been specially devised to help you get through your exams with ease. Completely revised throughout, the new edition of Crash Course is perfectly tailored to meet your needs by providing everything you need to know in one place. Clearly presented in a tried and trusted, easy-to-use, format, each book in the series gives complete coverage of the subject in a no-nonsense, user-friendly fashion. Commencing with 'Learning Objectives', each chapter guides you succinctly through the topic, giving full coverage of the curriculum whilst avoiding unnecessary and often confusing detail. Each chapter is also supported by a full artwork programme, and features the ever popular 'Hints and Tips' boxes as well as other useful aide-mmoires. All volumes contain an up-to-date self-assessment section which allows you to test your knowledge and hone your exam skills. Authored by students or junior doctors - working under close faculty supervision - each volume has been prepared by someone who has recently been in the exam situation and so relates closely to your needs. So whether you need to get out of a fix or aim for distinction Crash Course is for you!! Energy metabolism I : the tca cycle Energy metabolism II : ATP generation Carbohydrate metabolism Lipid transport and metabolism Protein metabolism Purines, pyrimidines, and haem Glucose homeostasis Digestion, malnutrition, and obesity Vitamins and vitamin deficiencies Minerals and trace elements Clinical assessment of metabolic and nutritional disorders.