Current Topics in Innate Immunity II

Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases. Front Matter....Pages i-xvii Pentraxins in Humoral Innate Immunity....Pages 1-20 Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution....Pages 21-36 The Role of Innate Immunity in Trafficking of Hematopoietic Stem Cells—An Emerging Link Between Activation of Complement Cascade and Chemotactic Gradients of Bioactive Sphingolipids....Pages 37-54 Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds....Pages 55-68 Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity....Pages 69-85 A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects....Pages 87-112 Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins....Pages 113-133 Granzyme B: A New Crossroad of Complement and Apoptosis....Pages 135-146 Role of C3, C5 and Anaphylatoxin Receptors in Acute Lung Injury and in Sepsis....Pages 147-159 Complement Involvement in Neovascular Ocular Diseases....Pages 161-183 Platelets, Complement, and Contact Activation: Partners in Inflammation and Thrombosis....Pages 185-205 Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection....Pages 207-221 Function of Act1 in IL-17 Family Signaling and Autoimmunity....Pages 223-235 Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood....Pages 237-251 Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases....Pages 253-275 Monocyte-derived Inflammatory Dendritic Cells in the Granuloma During Mycobacterial Infection....Pages 277-293 NK/DC Crosstalk in Anti-viral Response....Pages 295-308 Innate-Adaptive Crosstalk: How Dendritic Cells Shape Immune Responses in the CNS....Pages 309-333 Nutritional Immunity: Homology Modeling of Nramp Metal Import....Pages 335-351 Back Matter....Pages 353-354 From a James Beard Cookbook Hall of Fame author, “healthier, deliciously creative, easy-to-make comfort foods—what could be better than that?” ( Sacramento Observer ) A good cook once said that a casserole is a blend of inspiration and what’s on hand. Add to that a generous helping of know-how, and you’ve got The Best Casserole Cookbook Ever . Call it a hotdish, covered dish, or casserole—in these pages, you’ll find one-dish meals for every season and any occasion, put together with James Beard Cookbook Hall of Famer Beatrice Ojakangas’s customary common sense and uncommon culinary flair. For breakfast, there are make-ahead strata and quiches or last-minute offerings like baked omelets and Eggs Florentine; for lunches and brunches, light fare or full-on midday meals; and for dinner a dizzying array of dishes, meaty or vegetarian, made with fresh ingredients or pantry staples—from Pork Chops with Apple Stuffing to Baked Spaghetti, Southwestern Beans, or Autumn Vegetable Stew. Leave room for dessert, because Ojakangas includes sweet casseroles like Mocha Fudge Pudding and Strawberry Rhubarb Crisp. You’ll even find bread here in casserole form, from sweet Cinnamon Bubble Bread to savory Cornmeal Spoon Bread and tender Sally Lunn. Ojakangas has advice for both expert and novice about ingredients, equipment, and meals. Combine that with whatever you have in the pantry and fridge, and this cookbook is the perfect guide to everything that a casserole might be. “Any of these casserole recipes are great to take to parties, church dinners, or community potlucks. . . . In any season, casseroles can be comfort food at its finest.” — The Blade “Inventive and exhaustive.” — Star Tribune A good cook once said, a casserole is a blend of inspiration and what s on hand. Beatrice Ojakangas must have inspiration by the gallon, along with a very big kitchen, to come up with 500 comforting and creative casseroles ideal for any occasion. The enduring beauty of casseroles is that they come together quickly and they taste great the perfect dish doesn t get much better than that. The variety and versatility of these recipes will tempt you to make a casserole for every meal. Begin with a breakfast of Eggs Florentine, followed by Sweet & Sour Chicken for lunch, Pork Chops with Apple Stuffing for dinner, and Mocha Fudge Pudding for dessert. For the big family reunion, try Baked Spaghetti and Meatballs. Having an intimate dinner for two? Individual casseroles of Chicken Breast with Morel Mushrooms will make it both special and simple. Plenty of hearty dishes for vegetarians include the Latin-inspired Cornbread-Topped Black Bean Casserole and the Autumn Vegetable Stew (loaded.. A good cook once said that a casserole is a blend of inspiration and what's on hand. Beatrice Ojakangas must have had inspiration by the gallon to come up with these 500 casseroles. From a breakfast of Eggs Florentine to a dinner of Pork Chops with Apple Stuffing, soon even the most casserole-wary cook will be dishing about these delights. Yummy treats like Parmesan and Sun-Dried Tomato Quiche and Strawberry Rhubarb Crisp are just right for parties. Even appetizers are reinvented in casserole form! The Best Casserole Cookbook Ever will inspire comforting dishes and innovative feasts for any meal of the day—no matter what's in the fridge. 500 casserole recipes featuring updated, fresh ingredients for appetizers, breakfasts, brunches, main courses, vegetarian and even desserts