Developmental Neurobiology

In our attempts to interrogate Nature about the development of the nervous system, we ask such questions as "How do the nerve cells originate and how do the correct types of cells differentiate at their correct positions; how do the neurons link together to form circuits whose functions are properly coordinated; and how are the functions of nerve cells related to behavior, to thought, and to conscious­ ness?" Those problems are intellectually challenging, not only because solving them would give us practical advantages but also because while they remain unsolved they stimulate the imagination and challenge the intelligence. It is precisely because they are difficult and controversial and have defied complete solution that such problems continue to attract subtle minds. The understanding that we now have of neural ontogeny seems to me to be farther from complete knowledge than from total ignorance. Nonetheless, it gives us a slightly elevated position from which to survey the vicissitudes of the past, to appraise our present understanding, and to consider ways in which our knowl­ edge might develop in the future. The history of this subject affords a particularly piquant illustration of Arthur Lovejoy's comment that the "adequate record of even the confusions of our forebears may help, not only to clarify those confu­ sions, but to engender a salutary doubt whether we are wholly immune from different but equally great confusions. Front Matter....Pages i-xii Introduction....Pages 1-3 Beginnings of the Nervous System....Pages 5-25 The Germinal Cell and Histogenesis of the Nervous System....Pages 27-55 Histogenesis and Morphogenesis of the Central Nervous System....Pages 57-114 Differentiation, Growth, and Maturation of Neurons....Pages 115-180 Elaboration of Dendrites and Synaptic Connections....Pages 181-217 Dependence of the Developing Nervous System on Nutrition and Hormones....Pages 219-251 Cellular Interactions and Interdependence during Development of the Nervous System....Pages 253-307 Development of Peripheral Neural Connections with Muscles and Sensory Receptors....Pages 309-344 Neuronal Specificity and Development of Neuronal Circuits....Pages 345-433 Back Matter....Pages 435-562