Disordered Pharmaceutical Materials: Descamps/Disordered Pharmaceutical Materials

A one-stop resource for researchers and developers, this handbook and ready reference provides detailed, but not overloaded information -- presenting the topic without unnecessarily complex formalism. As such, it gives a systematic and coherent overview of disordered materials for pharmaceutical applications, covering fundamental aspects, preparation and characterization techniques as well as molecular modeling approaches for the target-oriented development of drug delivery systems based on amorphous solids. Chapters on the challenges of using these materials in large-scale processes in the pharmaceutical industry and on patenting issues round off the book. For pharmaceutical and medicinal chemists, materials scientists, clinical physicists, and pharmaceutical laboratories looking to make better and more potent pharmaceuticals. Some Facets Of Molecular Disorder In Crystalline And Amorphous Pharmaceuticals / Marc Descamps, Jean-françois Willart -- Influence Of Disorder On Dissolution / Khushboo Kothari, Raj Suryanarayanan -- Crystal Imperfections In Molecular Crystals: Physical And Chemical Consequences / William Jones, Mark D Eddleston -- Observation And Characterization Of Crystal Defects In Pharmaceutical Solids / Mark D Eddleston, William Jones -- Enantiomeric Disorder Pharmaceutically Oriented / Gerard Coquerel, Rui Tamura -- Conformational Disorder And Atropisomerism In Pharmaceutical Compounds / Attilio Cesàro, Barbara Bellich, Giovanna Giannini, Alessandro Maiocchi -- Tautomerism In Drug Delivery / Zaneta Wojnarowska, Marian Paluch -- Disorders In Pharmaceutical Polymers / Emeline Dudognon, Sheng Qi -- Polymer Gels, Hydrogels, And Scaffolds -- an Overview / Madeleine Djabourov, Kawthar Bouchemal -- Use Of The Pair Distribution Function Analysis In The Context Of Pharmaceutical Materials / Pierre Bordet, Pauline Martinetto -- Application Of Broadband Dielectric Spectroscopy To Study Molecular Mobility In Pharmaceutical Systems / Katarzyna Grzybowska, Karolina Adrjanowicz, Marian Paluch -- Raman Spectroscopy In Disordered Molecular Compounds: Application To Pharmaceuticals / Alain Hedoux -- Study Of Disordered Materials By Terahertz Spectroscopy / Juraj Sibik, J Axel Zeitler -- Study Of Disorder By Solid-state Nmr Spectroscopy / Marco Geppi, Silvia Borsacchi, Elisa Carignani -- Processing-induced Disorder In Pharmaceutical Materials / Sheng Qi -- Patenting Of Inventions Relating To Solid Forms, With Special Considerations On Disordered Forms / Bertrand Gellie. Edited By Marc Descamps. Includes Bibliographical References And Index. Mode Of Access: World Wide Web. Content: Some Facets of Molecular Disorder in Crystalline and Amorphous Pharmaceuticals / Marc Descamps, Jean-François Willart -- Influence of Disorder on Dissolution / Khushboo Kothari, Raj Suryanarayanan -- Crystal Imperfections in Molecular Crystals: Physical and Chemical Consequences / William Jones, Mark D Eddleston -- Observation and Characterization of Crystal Defects in Pharmaceutical Solids / Mark D Eddleston, William Jones -- "Enantiomeric Disorder" Pharmaceutically Oriented / Gerard Coquerel, Rui Tamura -- Conformational Disorder and Atropisomerism in Pharmaceutical Compounds / Attilio Cesàro, Barbara Bellich, Giovanna Giannini, Alessandro Maiocchi -- Tautomerism in Drug Delivery / Zaneta Wojnarowska, Marian Paluch -- Disorders in Pharmaceutical Polymers / Emeline Dudognon, Sheng Qi -- Polymer Gels, Hydrogels, and Scaffolds – An Overview / Madeleine Djabourov, Kawthar Bouchemal -- Use of the Pair Distribution Function Analysis in the Context of Pharmaceutical Materials / Pierre Bordet, Pauline Martinetto -- Application of Broadband Dielectric Spectroscopy to Study Molecular Mobility in Pharmaceutical Systems / Katarzyna Grzybowska, Karolina Adrjanowicz, Marian Paluch -- Raman Spectroscopy in Disordered Molecular Compounds: Application to Pharmaceuticals / Alain Hedoux -- Study of Disordered Materials by Terahertz Spectroscopy / Juraj Sibik, J Axel Zeitler -- Study of Disorder by Solid-State NMR Spectroscopy / Marco Geppi, Silvia Borsacchi, Elisa Carignani -- Processing-Induced Disorder in Pharmaceutical Materials / Sheng Qi -- Patenting of Inventions Relating to Solid Forms, with Special Considerations on Disordered Forms / Bertrand Gellie.

All areas of (bio-) inorganic chemistry depend on a variety of physical methods and instruments to characterize molecules and materials and their reactions. It is difficult, however, for newcomers to the field, and even experts in allied fields, to establish the utility of a given physical method for the characterization of their particular system.

This book provides a practical introduction to a comprehensive set of physical methods that have been applied to (bio-)inorganic systems, with an emphasis on answering questions such as, "what kind of information would this method provide?" or "what type of sample can be examined?" and, more importantly, "what information will not be available if I employ this method (i.e, what are its limitations)? The book provides a quick reference guide (like the "Quick Start" manuals that often come with computers and peripherals) that non-experts can consult to select physical methods appropriate for the characterization of a given materials.

Each method is introduced by a Methods Summary. These summaries are structured consistently to quickly answer practical questions about what information is, and is not, available using each technique, and what kinds of materials can be probed. Thus, at a glance, a non-expert can identify potentially useful methods, and then concentrate on those chapters to determine which methods will be most useful for solving their problem with specific examples of how that method is utilized. Researchers will also find sufficient information to determine if collaboration with others is the best course of action.

A one-stop resource for researchers, developers, and post graduate students in pharmaceutical science. This handbook and ready reference provides detailed, but not overloaded information -- presenting the topic without unnecessarily complex formalism.
As such, it gives a systematic and coherent overview of disordered materials for pharmaceutical applications, covering fundamental aspects, as well as preparation and characterization techniques for the target-oriented development of drug delivery systems based on disordered crystals and amorphous solids. Special attention is paid to examine the different facets and levels of disorder in their structural and dynamic aspects as well as the effect of disorder on dissolution and stability. Chapters on processing induced disorder and on patenting issues round off the book. As a result the book helps overcoming the challenges of using these materials in the pharmaceutical industry.
For pharmaceutical and medicinal chemists, materials scientists, clinical physicists, and pharmaceutical laboratories looking to make better and more potent pharmaceuticals.

Modern spectroscopic and instrumental techniques are essential to the practice of inorganic and bioinorganic chemistry. This first volume in the new Wiley Encyclopedia of Inorganic Chemistry Methods and Applications Series provides a consistent and comprehensive description of the practical applicability of a large number of techniques to modern problems in inorganic and bioinorganic chemistry. The outcome is a text that provides invaluable guidance and advice for inorganic and bioinorganic chemists to select appropriate techniques, whilst acting as a source to the understanding of these methods. This volume is also available as part of Encyclopedia of Inorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007 to 2010, representing areas of key developments in the field of inorganic chemistry published in the Encyclopedia of Inorganic Chemistry. Find out more. Modern spectroscopic and instrumental techniques are essential to the practice of inorganic and bioinorganic chemistry. This text provides a consistent and comprehensive description of the practical aaplicability of a large number of techniques to modern problems in organic and bioinorganic chemistry This one-stop resource for researchers and developers provides detailed, but not overloaded information -- presenting the topic without unnecessarily complex formalism. A systematic and coherent overview of disordered materials with a focus on pharmaceutical applications.