__Epigenetics and Dermatology__ explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. • Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes.• Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials.• Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy. Content: Front-matter, Pages i,iii Copyright, Page iv Dedication, Page v List of Contributors, Pages xiii-xvi, Nezam Altorok, Jack L. Arbiser, Michael Y. Bonner, Wesley H. Brooks, Christopher Chang, Jessica Charlet, Frederic L. Chedin, Hui-Min Chen, Suresh de Silva, Pierre Gazeau, M. Eric Gershwin, Yixing Han, Christian M. Hedrich, Yu-Ping Hsiao, Jared Jagdeo, Yi-Ju Lai, Christelle Le Dantec, Chih-Hung Lee, Jeung-Hoon Lee, Yungling Leo Lee, Patrick S.C. Leung, et al. Preface, Pages xvii-xviii, Qianjin Lu, Christopher C. Chang, Bruce C. Richardson Acknowledgments, Page xix Chapter 1 - Introduction to Epigenetics, Pages 3-6, Yu Liu, Qianjin Lu Chapter 2 - Laboratory Methods in Epigenetics, Pages 7-35, Yu Liu, Jieyue Liao, Qianjin Lu Chapter 3 - Keratinocyte Differentiation and Epigenetics, Pages 37-52, Jeung-Hoon Lee Chapter 4 - Epigenetics and Fibrosis: Lessons, Challenges, and Windows of Opportunity, Pages 53-74, Bin Liu, Xin Sheng Wang, Hui-Min Chen, Lu Qianjin, M. Eric Gershwin, Patrick S.C. Leung Chapter 5 - Epigenetic Modulation of Hair Follicle Stem Cells, Pages 75-84, Haijing Wu Chapter 6 - Epigenetics and the Regulation of Inflammation, Pages 85-111, Christian M. Hedrich Chapter 7 - Malignant Transformation and Epigenetics, Pages 113-135, Yixing Han, Jianke Ren, Weishi Yu, Minoru Terashima, Kathrin Muegge Chapter 8 - Epigenetic Mechanisms of Sirtuins in Dermatology, Pages 137-175, Alexander Lo, Melissa Serravallo, Jared Jagdeo Chapter 9 - MicroRNAs in Skin Diseases, Pages 177-205, Marianne B. Løvendorf, Lone Skov Chapter 10 - Systemic Lupus Erythematosus, Pages 209-226, Bruce C. Richardson Chapter 11 - Epigenetics in Psoriasis, Pages 227-248, Kuan-Yen Tung, Fu-Tong Liu, Yi-Ju Lai, Chih-Hung Lee, Yu-Ping Hsiao, Yungling Leo Lee Chapter 12 - Epigenetics and Systemic Sclerosis, Pages 249-273, Nezam Altorok, Amr H. Sawalha Chapter 13 - Epigenetics of Allergic and Inflammatory Skin Diseases, Pages 275-306, Nina Poliak, Christopher Chang Chapter 14 - Epigenetics and Other Autoimmune Skin Diseases, Pages 307-326, Ming Zhao, Ruifang Wu, Qianjin Lu Chapter 15 - Epigenetics and Infectious Skin Disease, Pages 329-338, Jack L. Arbiser, Michael Y. Bonner Chapter 16 - Epigenetics of Melanoma, Pages 339-361, Jessica Charlet, Gangning Liang Chapter 17 - Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome, Pages 363-377, Henry K. Wong, Li Wu, Suresh de Silva, Pierluigi Porcu, Anjali Mishra Chapter 18 - Epigenetics and Aging, Pages 379-406, Sabita N. Saldanha, Louis Patrick Watanabe Chapter 19 - Targeting Epigenetics in the Development of New Diagnostic Applications—Lessons from Autoimmune Diseases, Pages 409-441, Hui-Min Chen, Frederic L. Chedin, Christopher Chang, Patrick S.C. Leung Chapter 20 - Principles of Epigenetic Treatment, Pages 443-465, Shannon Doyle Tiedeken, Christopher Chang Chapter 21 - How the Environment Influences Epigenetics, DNA Methylation, and Autoimmune Diseases, Pages 467-485, Christelle Le Dantec, Pierre Gazeau, Sreya Mukherjee, Wesley H. Brooks, Yves Renaudineau Index, Pages 487-504
Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable.
• Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes.
• Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials.
• Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy.
