Eukaryotic Cell Genetics (Cell Biology)

Eukaryotic Cell Genetics reviews the state of knowledge in somatic cell genetics. The book begins by discussing the development of somatic cell genetics, focusing on the estimation of mutation rates in mammalian cells, with frequent reference to the use of drug resistance as a selective character. It then considers some of the specific properties of such variants in order to understand their molecular basis. The subsequent chapters examine the properties of specific types of auxotrophic variants; the means by which eukaryotic cells may be reassembled to give rise to viable cellular composites; gene regulation in eukaryotic organisms; and chromosome mapping. The discussions also include differentiation in cultured cells; neoplastic transformation; the modulation of gene expression in cultured cells; mutation induction in cultured cells; applications of cell culture; and the mechanism of cellular aging. This book is intended for researchers in the fields of genetics and molecular biology, nonspecialists interested in what is happening in a very exciting area of biology, and students at the graduate level in cell biology. Content: Front Matter , Page iii Copyright , Page iv PREFACE , Pages xi-xii 1 - Somatic Cell Genetics and the Legacy of Microbial Systems , Pages 1-13 2 - Drug Resistance and Its Genetic Basis , Pages 14-39 3 - Auxotrophic Variants in Cultured Cells , Pages 40-55 4 - Mechanisms for the Exchange of Genetic Information in Cultured Cells , Pages 56-69 5 - The Regulation of Gene Expression in Heterokaryons , Pages 70-81 6 - Chromosome Mapping , Pages 82-98 7 - Differentiation in Cultured Cells: Liver Cells , Pages 99-112 8 - Differentiation in Cultured Cells: Muscle Cells, Melanoma Cells, Neuronal Cells, and Hemoglobin-Producing Cells , Pages 113-127 9 - Differentiation in Cultured Cells: Cells of the Immune System , Pages 128-142 10 - Hypotheses of Malignancy and Their Analysis through the Use of Somatic Cell Hybrids , Pages 143-156 11 - Modulation of Gene Expression in Cultured Cells , Pages 157-173 12 - Mutation Induction in Cultured Cells , Pages 174-187 13 - Use of Cell Culture in the Analysis of Human Heredity , Pages 188-201 14 - The Cellular Basis of the Aging Process , Pages 202-214 15 - Future Outlook , Pages 215-224 Bibliography , Pages 225-255 Index , Pages 257-260 CELL BIOLOGY: A Series of Monographs , Pages ibc1-ibc2