Exploring Protein Structure: Principles and Practice (Learning Materials in Biosciences)

This textbook introduces the basics of protein structure and logically explains how to use online software to explore the information in protein structure databases. Readers will find easily understandable, step-by step exercises and video-trainings to support them in grasping the fundamental concepts. After reading this book, readers will have the skills required to independently explore and analyze macromolecular structures, will be versed in extracting information from protein databases and will be able to visualize protein structures using specialized software and on-line algorithms. This book is written for advanced undergraduates and PhD students wishing to use information from structural biology in their assignments and research and will be a valuable source of information for all those interested in applied and theoretical aspects of structural biology. Front Matter ....Pages I-X The Rationale Behind This Workbook (Tim Skern)....Pages 1-6 An Archive and a Tool: PDB and PyMOL (Tim Skern)....Pages 7-28 Exploring Fundamentals (Tim Skern)....Pages 29-60 Exploring the Peptide Bond (Tim Skern)....Pages 61-83 Exploring Secondary Structure Elements (Tim Skern)....Pages 85-123 Exploring Protein-Ligand and Protein-Protein Interactions (Tim Skern)....Pages 125-161 Examining α-Helical Proteins (Tim Skern)....Pages 163-196 Investigating Proteins with β-Sheets (Tim Skern)....Pages 197-226 Moving from Former to Future Frontiers (Tim Skern)....Pages 227-247 Back Matter ....Pages 249-255