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Terms of use Copyright Introduction to the Series Related Titles from SPIE Press Preface Glossary of Symbols and Notation Introduction and Definitions Motivation What Is a Biosensor? Elements of a Biosensor Example: Immunochromatographic Assays Types of Biosensors Non-optical Biosensors Optical Biosensors Background History of Biosensors Early Milestones in the Development of Biosensors Later Milestones in the Development of Biosensors Surface Functionalization and Immobilization of Bioreceptors Immobilization of Bioreceptors From Surface Functionalization to Analyte Capture Common Bioreceptors More Bioreceptors Usual Methods of Immobilization Performance Parameters Precision and Accuracy Repeatability, Reproducibility, and Selectivity Sensitivity Measurand, Full-Scale, and Dynamic Ranges Signal-to-Noise Ratio Minimum Detectable Signal and Saturation Time Factors and Stability Practical Aspects Resolution, Threshold, Calibration, and Hysteresis Linearity, Offset, and Overload Deviations from Ideality (Errors) The Ideal Biosensor Fundamental Optical Sensing Mechanisms Fundamental Optical Processes Transmission, Absorption, and Scattering Optical Phase Difference and Optical Path Difference Polarization Surface Plasmon Resonance Luminescence Photoluminescence Fluorescence Phosphorescence Fluorescence Polarization Detection Methods, Techniques, and Configurations Absorbance Biosensors Infrared Spectroscopy Infrared Vibrational Modes Scattering Detection Resonance Rayleigh Scattering Transduction Based on Reflectance andTransmittance Interferometric Biosensors Colorimetric Bioassays Biosensing Using Ellipsometry Photonic Crystals Fluorescence-Based Biosensing Fluorescence Polarization Detection Phosphorescence-Based Biosensing Chemiluminescence Bioluminescence Time-Resolved Fluorescence Evanescent Wave Biosensing Attenuated Total Reflection Spectroscopy Fiber-Optic Biosensors Near-Field Scanning Optical Microscopy Surface Plasmon Resonance Biosensors Real-Time SPR Sensing Phase-Sensitive Biosensing Optical Heterodyne Detection Polarimetry Photoacoustic Spectroscopy Raman Spectroscopy Surface-Enhanced Raman Scattering Detection Planar Optical Waveguides and IntegratedOptical Sensors Waveguide Interferometer Architectures Mach–Zehnder Interferometer Young Interferometer Hartmann Interferometer Dual Polarization Interferometry Bimodal Waveguide Interferometers Resonant Waveguide Grating Antiresonant Reflecting Optical Waveguides Hollow Waveguides Photonic Crystal Cavity Biosensors Resonant Optical Microcavities Beyond the Visible and Infrared Ranges Integrated Microfluidic Biosensors Lab-on-a-Chip Devices Bioimaging Applications Medicine Infections Caused by Pathogens Airborne Diseases Point-of-Care Testing Techniques Home Monitoring Optical Biosensors for Therapeutic Drug Monitoring Food Safety Common Foodborne Pathogens Food Industry Biosensors for the Detection of Foodborne Pathogens Defense Important Biological Warfare Agents Some Optical Biosensors for Biological Warfare Agents Homeland Security Environmental Applications Wearable and Implantable Biosensors Challenges in Biosensor Commercialization Equation Summary References Index Author biography