High-Throughput Analysis : A Tool for Combinatorial Materials Science

This book, edited by Potyrailo and Amis, addresses a new paradigm-shifting approach in the search for new materials-Combinatorial Materials Science. One way to consider such an approach is to imagine an adventurous chef who decides to look for new entrees by cooking food ingredients in many pots using different combinations in every pot, and boil­ ing, steaming, or frying them in various ways. Although most of the pots will not have the tastiest food ever devised, some recipes will taste intriguing, and some eventually will lead to a discovery of a new fascinating cuisine. Of course, having a skilled chef design the com­ binatorial formulation will certainly be helpful in ensuring a successful outcome. Similar to food, each engineering material is a complex product of its chemical composition, structure, and processing. Generally, each of these components matters---change one and you get another material. Most of these "new" materials will be less good than ones we use now since existing materials have been refined with the extensive work of scientists and engi­ neers. At the same time if one prepares diverse materials like our adventurous chef, chang­ ing material composition, processing conditions and time, etc. , some of these materials will be superior to existing ones and a few might represent breakout technology. Front Matter....Pages i-xxiii Elements of High-Throughput Analysis in Combinatorial Materials Science....Pages 1-13 Economic Impact of Combinatorial Materials Science on Industry and Society [1]....Pages 15-30 Front Matter....Pages 31-31 Image Analysis for High-Throughput Materials Science....Pages 33-56 Laser-Induced Fluorescence Detection in High-Throughput Screening of Heterogeneous Catalysts....Pages 57-76 Spectroscopic Imaging in the Mid-Infrared Applied to High-Throughput Studies of Supported Catalyst Libraries....Pages 77-91 Linear Spatially Encoded Combinatorial Chemistry with Fourier Transform Library Analysis....Pages 93-104 Front Matter....Pages 105-105 Separation Approaches Toward Rapid and Complex Molecular Characterization of Diverse Polymers....Pages 107-123 High-Throughput Gas Chromatography and Mass Spectrometry for Heterogeneous Catalysis: Screening of Catalytic Activities and Selectivities....Pages 125-153 Rapid Determination of Molecular Parameters of Synthetic Polymers Using Precipitation-Redissolution HPLC and a “Molded” Monolithic Column....Pages 155-186 Ion Mobility/Time-of-Flight Analysis of Combinatorial Library Mixtures....Pages 187-216 Front Matter....Pages 217-217 Acoustic Wave Sensors for High-Throughput Screening of Materials....Pages 219-246 High-Throughput Screening of Oxidation Catalysts with Gas Sensors....Pages 247-259 Optical Sensing Methods in High-Throughput Screening....Pages 261-288 Combinatorial Study and High-Throughput Screening of Transparent Barrier Films using Chemical Sensors....Pages 289-316 Intrinsic Fiber-Optic Sensors for Spatially Resolved Combinatorial Screening....Pages 317-345 Front Matter....Pages 347-347 Diffusion Multiples for High-Efficiency Alloy Design....Pages 349-375 Combinatorial and Spread Techniques in the Fabrication of Organic-Based Photonic and Optoelectronic Devices....Pages 377-393 High-Throughput Conductivity Measurements of Thin Films....Pages 395-413 Development of High-Throughput Methods for Polymer Nanocomposite Research....Pages 415-427 Front Matter....Pages 429-429 Combinatorial Electropolymerization: Concept, Equipment, and Applications....Pages 431-446 Front Matter....Pages 429-429 Principles and Applications of Combinatorial Electrochemistry....Pages 447-466 Front Matter....Pages 467-467 Ink-Jet Methods in Combinatorial Materials Synthesis....Pages 469-490 Miniaturized Reactor Concepts and Advanced Analytics for Primary Screening in High-Throughput Experimentation....Pages 491-523 A High-Throughput Cross-Linker Evaluation for Polyurethane Dispersions....Pages 525-549 Data Management for Combinatorial Heterogeneous Catalysis: Methodology and Development of Advanced Tools....Pages 551-579 Scaling Up of Catalysts Discovered from Small-Scale Experiments....Pages 581-609 Combinatorial Development of Organic Clear Coatings for Plastic Substrates and Scale-Up of Combinatorial Leads....Pages 611-630 Back Matter....Pages 631-638 This is the first practical reference book that covers state of the art analytical methods, instrumentation and data processing techniques used for high-throughput analysis of new materials in combinatorial chemistry and materials science beyond the pharmaceutical area. This book demonstrates how these techniques are applied for development of new materials on combinatorial scale and for scale-up of combinatorial materials leads. The book is written by an international team of contributing authors and consists of 27 chapters that detail the most recent advances in optical imaging and spectroscopy; separations and mass spectrometry; sensors and sensor arrays; analysis of mechanical, electrical, and thermal properties; electrochemical analysis; fabrication of combinatorial libraries; data management, and scale-up of combinatorially discovered materials. High-Throughput Analysis provides multi-disciplinary practitioners and beginners with a treatment of the principles, methodology, and characteristics of instrumentation for high-throughput analysis in order to stimulate further research in this rapidly expanding field.