The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. This new edition continues to cover both basic and up-to-date material on normal and defective chromosomes, yet is particularly strengthened by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects. The mapping and molecular analysis of chromosomes is one of the most exciting and active areas of modern biomedical research, and this book will be invaluable to scientists, students, technicians and physicians with an interest in the function and dysfunction of chromosomes. Front Matter....Pages i-xvi Origins and Directions of Human Cytogenetics....Pages 1-11 The Mitotic Cell Cycle....Pages 13-27 DNA Replication and Chromosome Reproduction....Pages 29-44 General Features of Mitotic Chromosomes....Pages 45-59 The Chemistry and Packaging of Chromosomes....Pages 61-77 Chromosome Bands....Pages 79-94 Molecular Correlates of Chromosome Bands....Pages 95-105 In Situ Hybridization....Pages 107-124 Main Features of Meiosis....Pages 125-140 Details of Meiosis....Pages 141-155 Meiotic Abnormalities: Abnormal Numbers of Chromosomes....Pages 157-174 Abnormal Phenotypes Due to Autosomal Aneuploidy or Polyploidy....Pages 175-185 Chromosome Structural Aberrations....Pages 187-205 The Causes of Structural Aberrations....Pages 207-221 Syndromes Due to Autosomal Deletions and Duplications....Pages 223-237 Clinical Importance of Translocations, Inversions, and Insertions....Pages 239-254 Sex Determination and the Y Chromosome....Pages 255-266 The X Chromosome, Dosage Compensation, and X Inactivation....Pages 267-281 Phenotypic Effects of Sex Chromosome Imbalance....Pages 283-294 Fragile Sites, Trinucleotide Repeat Expansion, and the Fragile X Syndrome....Pages 295-308 Euploid Chromosome Aberrations, Uniparental Disomy, and Genomic Imprinting....Pages 309-322 Chromosome Changes in Cell Differentiation....Pages 323-338 Somatic Cell Hybridization in Cytogenetic Analysis....Pages 339-351 Chromosome Instability Syndromes....Pages 353-367 DNA and Gene Amplification....Pages 369-383 Genome Destabilization and Multistep Progression to Cancer....Pages 385-403 Chromosomes and Cancer: Activation of Oncogenes....Pages 405-414 Chromosomes and Cancer: Inactivation of Tumor Suppressor Genes....Pages 415-430 Mapping Human Chromosomes....Pages 431-446 Genome Plasticity and Chromosome Evolution....Pages 447-461 The Future of Human Cytogenetics....Pages 463-474 Back Matter....Pages 475-501
The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. It covers both basic and up-to-date material on normal and defective chromosomes. This new edition is particularly strengthened by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects. The mapping and molecular analysis of chromosomes is one of the most exciting and active areas of modern biomedical research, and this book will be invaluable to scientists, students, technicians and physicians with an interest in the function and dysfunction of chromosomes.
From the reviews of the third edition: Each word tells in this concise gem of a human cytogenetics text...Superb organization makes this an excellent text...for any cytogenetics course. American Journal of Human Genetics
...the leading textbook in English on human cytogenetics. Cell
The fourth edition of this well-known text provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes. It covers both basic and up-to-date material on normal and defective chromosomes. This new edition is particularly strengthened by the complete revision of the material on the molecular genetics of chromosomes and chromosomal defects. The mapping and molecular analysis of chromosomes is one of the most exciting and active areas of modern biomedical research, and this book will be invaluable to scientists, students, technicians and physicians with an interest in the function and dysfunction of chromosomes. From the reviews of the third edition: "Each word "tells" in this concise gem of a human cytogenetics text ... Superb organization makes this an excellent text ... for any cytogenetics course." American Journal of Human Genetics " ... the leading textbook in English on human cytogenetics." Cell This is the fourth edition of an acclaimed introductory textbook on the structure and function of human chromosomes. The explosion of information on human genetic diseases has meant that there is a greater need than ever for students, practising physicians, laboratory technicians, and researchers to have a concise, up-to-date summary of the normal and abnormal behavior of chromosomes. This book continues to fulfill that need, and is strengthened by the complete revision of material on the molecular genetics of chromosomes and chromosomal defects. The fourth edition of this well known book provides students, researchers and technicians in the area of medicine, genetics and cell biology with a concise, understandable introduction to the structure and behavior of human chromosomes.
