This fourth edition of Huntington's Disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002. Completely updated and expanded, chapters in this volume are organized in five sections: · Clinical aspects of Huntington's disease, including updated chapters on historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and new chapters on juvenile Huntington's and the premanifest and early stages · The genetics of Huntington's disease, including new information on its epidemiology discussions of new testing guidelines · Neurobiology, including recent insights into correlations between pathology and symptoms and a new chapter on neuronal circuitry · The molecular biology of Huntington's disease, including new chapters on the normal function of huntingtin, the molecular pathogenesis of Huntington's disease and the peripheral pathology of the disorder, and an extensively updated chapter on its structural biology · An updated description of the comprehensive care for Huntington's disease, featureing a new chapter on preclinical therapeutics and a completely rewritten chapter on the state of the art of experimental therapeutics and clinical trials. Cover Huntington’s Disease Series Copyright Contents Contributors Section one Clinical Aspects of Huntington’s Disease 1 Huntington’s Disease in a Historical Context 2 Clinical Neurology 3 Neuropsychiatry and Neuropsychology 4 Juvenile Huntington’s Disease 5 Premanifest and Early Huntington’s Disease Section two Genetics of Huntington’s Disease 6 Genetic and Molecular Studies 7 Epidemiology 8 Genetic Counseling and Testing Section three Neurobiology of Huntington’s Disease 9 Neuropathology in the Human Brain 10 Altered Neuronal Circuitry Section Four Molecular Biology of Huntington’s Disease 11 Normal Function of Huntingtin 12 Structural Biology: Order, Disorder, and Conformational Flux 13 Pathogenic Mechanisms 14 Peripheral Pathology Section five Therapeutic Interventions in Huntington’s Disease 15 Comprehensive Care 16 Preclinical Experimental Therapeutics 17 Experimental Therapeutics: Moving Forward in Clinical Trials Index This fourth edition of Huntington's Disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002. Completely updated and expanded, chapters in this volume are organized in five sections: DT Clinical aspects of Huntington's disease, including updated chapters on historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and new chapters on juvenile Huntington's and the premanifest and early stages DT The genetics of Huntington The fourth edition of the preeminent resource on Huntington's disease is a comprehensive resource on the current knowledge base surrounding this disease. Comprising both updated chapters and seven entirely new chapters, it reflects the major advances that have recently occurred in our understanding of all aspects of this disease
