Imaging in neurodegenerative disorders

Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders. Imaging in Neurodegenerative Disorders covers all the imaging techniques and new exciting methods like new tracers, biomarker, metabolomic and gene-array profiling, potential for applying such techniques clinically, and offers present and future applications as applied to the neurodegenerative disorders with the most world renowned scientists in these fields. This book is an invaluable resource for researchers, clinicians, and trainees in neuroscience, neurology, psychiatry, and radiology. Cover Imaging in Neurodegenerative Disorders Copyright Dedication Contents List of abbreviations List of contributors SECTION 1 Introduction 1 Epidemiology of neurodegenerative diseases 2 Metabolomics of neurodegenerative disorders 3 Transcriptome profiling in neurodegenerative disorders 4 Health economic considerations in neurodegenerative disorders 5 Symptoms of neurodegenerative diseases SECTION 2 Imaging technique 6 Computed tomography 7 General principles of magnetic resonance imaging 8 Nuclear medicine and radiology 9 Molecular imaging and neurodegenerative disorders 10 Positron emission tomography in neurodegenerative disorders-evolving techniques and new tracers11 Radiopharmaceuticals for molecular imaging of neurodegenerative diseases SECTION 3 Neurodegeneration: cognition 12 Neuroimaging of Alzheimer's disease 13 MRI-based imaging of Alzheimer's disease 14 Frontotemporal dementia 15 Dementia with Lewy bodies 16 Corticobasal syndrome and corticobasal degeneration SECTION 4 Neurodegeneration: movement 17 Parkinson's disease: clinical and imaging features 18 Progressive supranuclear palsy 19 Imaging in Huntington's disease 20 Multiple system atrophy21 Clinical benefit of dopamine transporter imaging in movement disorders and dementia SECTION 5 Neurodegeneration: strength 22 Amyotrophic lateral sclerosis SECTION 6 Neurodegeneration: coordination 23 Spinocerebellar atrophies 24 Imaging in Friedreich's ataxia 25 Neuroimaging in human prion diseases SECTION 7 Neurodegeneration: peripheral and autonomic nervous systems 26 Amyloidosis 27 Neurodegeneration: metabolic and toxin-related disorders SECTION 8 Neurodegeneration: myelin 28 Demyelinating diseases 29 Charcot-Marie-Tooth disease 30 Neurodegenerative disorders of the basal gangliaSECTION 9 Neurodegeneration: trauma 31 Neurodegeneration post trauma: brain 32 Neurodegeneration post trauma: spine 33 Neurodegeneration after trauma: peripheral nerves SECTION 10 Neuroimaging after therapy 34 Functional imaging of neurosurgery in Parkinson's disease 35 Neuroimaging after cell-based therapy Index This resource covers all the imaging techniques associated with investigations and diagnoses in neurology for neurodegenerative disorders, as well as new methods such as new tracers, biomarker, gene-array profiling, & the potential for applying such techniques clinically. As new imaging modalities have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders, the resource discusses high resolution, morphological, metabolic and functional analysis, as well as computed tomography, magnetic resonance, nuclear medicine and molecular imaging Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders. __Imaging in Neurodegenerative Disorders__ This book summarizes the latest developments in imaging techniques and other new diagnostic methods as applied to the neurodegenerative disorders.