Maspin (Medical Intelligence Unit, Unit 32)

This book represents the first compilation of the major research findings regarding Maspin—a mammary serpin (or serine) protease inhibitor. Maspin was originally discovered through subtractive hybridization and differential display analyses, comparing the differences in gene expression in normal mammary epithelium and invasive carcinoma cells. This work originated in the laboratory of Dr. Ruth Sager, a world-renowned geneticist, at the Dana Farber Cancer Institute and Harvard Medical School. The first introduction of Maspin to the research community occurred as a report in Science (v263:526-529, 1994), and described the unique tumor-suppressing activity of this novel gene in human mammary epithelial cells. Table of ContentsRuth Sager, geneticistArthur B. PardeeMaspin in the Sager laboratoryMing Zhang et alMaspin: functional insights from a structural perspectivePhilip PembertonMaspin and Myoepithelial CellsSanford H. Barsky et alMaspin and pericellular plasminogen activation in cell-matrix interactionShijie Sheng et alGenetic and epigenetic regulation of maspin gene expression in normal and tumor tissueFrederick Domann et alMolecular regulation of maspin's inhibitory effects on tumor cell invasionRichard Seftor e This book represents the first compilation of the major research findings regarding Maspin a mammary serpin (or serine) protease inhibitor. Maspin was originally discovered through subtractive hybridization and differential display analyses, comparing the differences in gene expression in normal mammary epithelium and invasive carcinoma cells. T