Mechanisms of Heart Failure

__Mechanisms of Heart Failure__ is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings. Front Matter....Pages i-xxv Front Matter....Pages 1-1 Tumor Necrosis Factor-Alpha in Chronic Heart Failure....Pages 3-8 Myocardial Ribonuclease Activity in Heart Failure....Pages 9-18 β-Adrenergic Receptor Mechanisms in Heart Failure....Pages 19-35 Vascular α-Adrenergic Function in Congestive Heart Failure....Pages 37-50 Altered Myocardial Neurotransmitter and 1,2-Diacylglycerol Concentrations in Right Ventricular Hypertrophy and Failure in Rats....Pages 51-62 Metabolic Changes in Nonischemic Myocardium During Pump Failure....Pages 63-74 Cardiac Extracellular Matrix and its Role in the Development of Heart Failure....Pages 75-90 SHHF/Mcc-/ fa cp Rat Model: A Genetic Model of Congestive Heart Failure....Pages 91-106 Left Ventricular Mass and Diastolic Function in Young Individuals With a First Elevated “Casual” Blood Pressure....Pages 107-115 Factors Responsible for Left Ventricular Underfilling in Pure Mitral Stenosis....Pages 117-127 Improved Preservation of Myocardial Ultrastructure in Perfusion-Fixed Human Heart Explants....Pages 129-141 Involvement of Leukotoxin in the Pathogenesis of Patients with Extensive Burns....Pages 143-151 Differential Regulation of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase Isozymes....Pages 153-166 Front Matter....Pages 167-167 Adriamycin Cardiomyopathy and Its Prevention in an Animal Model....Pages 169-176 Alterations in Sarcolemmal Phospholipid Base Exchange Enzymatic Activities in Diabetic Cardiomyopathy....Pages 177-184 Myocardial Lipid Peroxidation and Diabetes....Pages 185-195 Molecular biologic Changes of Adenine Nucleotide Translocator in J-2-N Cardiomyopathic Hamsters....Pages 197-202 Renin-Angiotensin System and the Congenital Cardiomyopathic Hamster....Pages 203-214 Dietary Mercury Induces Congestive Cardiomyophaty in the Arctic....Pages 215-219 Peripheral Resistance to Atrial Natriuretic Peptide in Patients with Idiopathic Dilated Cardiomyopathy....Pages 221-238 Front Matter....Pages 167-167 Effect of Ethanol on Allylamine-Induced Subendocardial Fibrosis....Pages 239-248 Nitric Oxide: Friend and Foe in Myocardial Ischemia and Reperfusion....Pages 249-262 Role of Leukocytes and Subcellular Abnormalities in Diastolic Dysfunction During Ischemia-Reperfusion....Pages 263-276 Calcium Channel Blockade Ameliorates Cardiac Dysfunction and Failure in Ischemic Cardiomyopathy....Pages 277-294 Alterations in Autonomic Nervous System and Heart Mitochondrial Function in Rats Treated with Cyclophosphamide....Pages 295-303 Front Matter....Pages 305-305 Combined Aerobic and Strength Training in Congestive Heart Failure Patients: Pilot Project on Saffty and Feasibility....Pages 307-314 Factors Relating to 6 Minute Walk Performance in Heart Failure Patients....Pages 315-322 Dynamic Cardiomyoplasty: The Management of Heart Failure Using Autologous Skeletal Muscle....Pages 323-336 Cardiac Cell Transplantation....Pages 337-347 Effects of Catalase on Volume-Overload Heart Failure....Pages 349-357 Major Determinants of Survival and Nonsurvival of Intra-Aortic Balloon Pumping....Pages 359-367 End-Stage Ischemic Heart Disease: Effects of Complete Myocardial Revascularization and Left Ventricular Patch Repair Following Scar Resection....Pages 369-374 Acute Enoximone Effect on Systemic Hemodynamics, Renal Function, and Hormonal Activation in Patients with Heart Failure....Pages 375-386 Angiotensin II Receptor Antagonist, E-4177, Inhibits Progression of Reactive Cardiac Hypertrophy Associated with Myocardial Infarction in Rats....Pages 387-400 Effects of Catecholamine and Amrinone on the Metabolism of Noninfarcted Myocardium in Cardiogenic Shock....Pages 401-410 Effects of Angiotensin Converting Enzyme Inhibitors on Acute Heart Failure Induced in the Anesthetized Dog with Microsphere Injection....Pages 411-424 Recruitment of Ventricular Function with Adjunctive Nitrate Therapy after Late Reperfusion....Pages 425-432 Neuromuscular Assessment of Heart Failure Patients....Pages 433-442 Back Matter....Pages 443-453