Well over one decade has passed since the appearance of the original four volumes of Membrane Transport in Biology. Since the publication of the last volume there have been spectacular advances in this field. These advances have been in part the result of the application of exciting new methodologies, and in part the result of new insights into the regulation and integration of transport processes. This volume, as well as a sixth volume, which is in preparation, are intended to cover key areas in which the development has been particularly striking. For many years the trend in studies of membrane transport had been that of increasing specialization with regard to the transporter of interest and of the cell or tissue studied. This trend was supported by the enormous number of publications directed at understanding the cellular physiology of specific organ systems and tissues, and also by the fact that different tissues often seemed to react so differently to the same conditions that mechanisms unique to each appear to be at play. One of the happy developments in recent years has been the realization that this apparent disparity of behaviors in different tissues is based on varying combinations of a limited number of transport mechanisms, all mediated by the same or similar proteins. Some of these transport proteins have already been isolated and analyzed with respect to amino acid sequence whereas others are just entering this phase. Volume 5 reviews recent advances in membrane transport, physiology, emphasizing transport mechanisms that have been foci for intensive investigation over the past 5 years. From this work, it has become abundantly clear that these same transport mechanisms are found in many different types of cells and tissues, but that they can be arranged in various combinations with other transporters in order to provide a givencell with unique transport characteristics. Similarly, distribution of thesemembrane transporters between apical and basolateral membranes in epithelia in various combinations with other transporters, can lead to unique transepithelial transport phenomena. Thus, the emphasis of the present volume is on the new information that has derived from these varioustransport systems, but with an emphasis on transportrs that are common to several cells. Rather than detailing specific characteristics of several specific cells and tissues, as had been done in the original four volumes of this book, this volume emphasizes the commonality of transport mechanisms shared by different cells and tissues and how they are integrated into varying cells functions Front Matter....Pages I-XI Na,K-ATPase, Structure and Transport Mechanism....Pages 1-55 Cell and Molecular Biology of Na + /Glucose Symport....Pages 56-72 Ion Channels in Epithelial Tissue: Single-Channel Properties....Pages 73-165 Amiloride-Sensitive Na + Transport Mechanisms....Pages 166-232 Anion Exchange Mechanism of Band 3 and Related Proteins....Pages 233-261 Cellular Calcium Transport Systems....Pages 262-316 Membrane Mechanisms in Volume Regulation in Vertebrate Cells and Epithelia....Pages 317-399 Back Matter....Pages 401-409
