Second author, Ruth J. Muschel, is with the Univ. of Pennsylvania, Philadelphia. Offers a comprehensive evaluation on the mechanisms of action of proteases and their inhibitors in tumor biology. Discusses clinical aspects and updated knowledge of cancer treatments. For physicians and researchers. Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the rescue of several of these genes and has situated them in the forefront of the current cancer research. However epigenetic silencing is also much more than aberrant DNA methylation, a whole set of histone modifiers and chromatin remodelling factors "conspire" to maintain the repression of these tumor/metastasis suppressor genes. DNA demethylating agents and inhibitors of histone deacetylases are the first generation of epigenetic drugs to beat them. In this book, the current directions in the epigenetics of cancer progression and metastasis are comprehensively described. It is now the turn of the reader to take care of the future. Dr Manel Esteller, Director, Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO) mesteller@cnio. How Cpg Island Hypermethylation Leads To Cancer Dissemination: The Sounds Of Silence For Tumor And Metastasis Suppressor Genes -- Mouse Skin Multistage Carcinogenesis Model That Unmasks Epigenetic Lesions Responsible For Metastasis -- Cpg Island Hypermethylation And Lung Cancer Invasion And Metastasis -- Cpg Island Hypermethylation Changes During Prostate Cancer Progression And Metastasis -- Cpg Island Hypermethylation In Breast Cancer Progression And Metastasis -- Epigenettic Dysregulation Of Maspin (serpinb5) In Cancer Invasion And Metastasis -- Epigenetic Regulation Of The E-cadherin Cell-cell Adhesion Gene -- Epigenetic Disruption Of The Slit-robo Interactions In Human Cancer -- Molecular Mechanisms Of The Metastasis-associated Gene Family Of Coregulators: Role In Cancer And Invasion -- Molecular Mechanisms For Breast Cancer Metastasis Suppressor 1 Action In Cancer Metastasis -- Mechanisms Of Dna Demethylating Drugs Against Cancer Progression -- Histone Deacetylase Inhibitors: Novel Targeted Anti-cancer Agents. Edited By Manel Esteller. Includes Bibliographical References. Mode Of Access: World Wide Web.
Distant metastases are the main cause of cancer-related death. The onset of the metastatic process can now be assessed in cancer patients by the use of immunocyhemical and molecular methods that allow the identification of disseminated carcinoma cells in regional lymph nodes, peripheral blood or distant organs. There is increasing evidence that the detection and characterization of tumor cells present in bone marrow or peripheral blood can provide clinically important information.
In this book, leading experts in the area of micrometastasis research provide an overview that summarizes the current state of research on micrometastatic disease in patients with solid tumors. In each chapter, the technical aspect as well as clinical relevance of micrometastasis detection is discussed.
The book addresses basic researchers as well as clinicians involved in the treatment of cancer patients.
Distant metastases are the main cause of cancer-related death. The onset of the metastatic process can now be assessed in cancer patients by the use of immunocytochemical and molecular methods that allow the identification of disseminated carcinoma cells in regional lymph nodes, peripheral blood or distant organs. There is increasing evidence that the detection and characterization of tumor cells present in bone marrow or peripheral blood can provide clinically important information. In this book, leading experts in the area of micrometastasis research provide an overview that summarizes the current state of research on micrometastatic disease in patients with solid tumors. In each chapter, the technical aspect as well as clinical relevance of micrometastasis detection is discussed. The book addresses basic researchers as well as clinicians involved in the treatment of cancer patients. In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account. This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication. Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer. Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies. The book provides an overview of molecular factors that offer targets and avenues for therapeutic strategies. "This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes."--BOOK JACKET
these Twelve Papers Evaluate The Mechanisms Of Action Of Proteases And Their Inhibitors In Tumor Biology. Beginning With A Selective Overview Of The Relevant Molecular Biology, The Book Evaluates The Physiological And Synthetic Inhibitors In The Various Models Of Experimental And Human Cancer. Specific Chapters Discuss Serine Proteases, Gelatinases, Membrane-type Matrix Metalloproteinases, Drug Design, Clinical Aspects, Tumor-stroma Interactions, And Mammalian Heparanase. Annotation ©2003 Book News, Inc., Portland, Or
Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer.
Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.
Provides an outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. This book describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. Dissemination of solid tumours in the bone marrow or blood stream has been described for a variety of malignancies. Genetic studies have provided important insights in proteinase biology.
