Clearly divided into three sections on the interface influence of materials and surface modifications, the physical and physicochemical surface characterization, and the biological characterization of the interface and biosystem reactions, this book is the first to concentrate on the highly important area of metal-based implants and their improved functionality and acceptance by the body.Content: Chapter 1 Introduction (pages 1–4): Prof. Dr. Jurgen BremeChapter 2 Metals and Alloys (pages 5–18): Stefan Winter, Dirk Velten, Frank Aubertin, Christa Sauer, Dirk Handtrack, Bernd Kieback, Gert Richter, Hartmut Worch and Wolfgang PompeChapter 3 Topological Surface Modifications (pages 19–50): Bettina Hoffmann, Gunter Ziegler, Regina Lange, Ulrich Beck, Lenka Muller, Egle Conforto, Frank A. Muller, Ulrich T. Seyfert, Frank Aubertin, Andre Gorbunoff, Wolfgang Pompe and Michael GelinskyChapter 4 Chemical Surface Modifications (pages 51–116): Stefan Winter, Dirk Velten, Frank Aubertin, Frank Heidenau, Gunter Ziegler, Frank A. Muller, Lenka Muller, Bettina Hoffmann, Volker Faust, Irina Dieser, Georg Lipps, Rainer Muller, Klaus Heckmann, Peter Angele, Richard Kujat, Michael Nerlich, David Tebbe, Uwe Gbureck, Prof. Dr. Roger Thull, Doris Klee, Jurgen Boing, Hartwig Hocker, Tilo Pompe, Carsten Werner and Hartmut WorchChapter 1 Introduction (pages 117–120): Prof. Dr. Roger ThullChapter 2 Surface Topology (pages 121–141): Ulrich Beck, Regina Lange and Prof. Dr. Roger ThullChapter 3 Spectroscopic Interface Characterization (pages 143–152): Andreas Zoll and Prof. Dr. Roger ThullChapter 4 Physical Characterization of Protein Adsorption: Time?Resolved Determination of Protein Adsorption Using Quartz Crystal Microgravimetry with Dissipation Monitoring (QCM?D) (pages 153–161): Claus Moseke, Rene Michalek and Prof. Dr. Roger ThullChapter 5 Computer Simulations: Modeling of Protein Adsorption on Nanostructured Metallic Surfaces (pages 163–169): Patrick Elter and Roger ThullChapter 1 Protein and Cell Adhesion Mechanisms (pages 171–189): Andrea Ewald, Patrick Elter, Prof. Dr. Roger Thull, J. G. Barbara Nebe, Frank Luthen, Thomas K. Monsees and Richard H. W. FunkChapter 2 Material?Induced Cellular Interactions (pages 191–213): Thomas K. Monsees, Richard H. W. Funk, Hartwig Wolburg, Friederike Pfeiffer, Andreas Heeren, Wolfgang Henschel, Jurgen Geis?Gerstorfer, Lutz Scheideler, Dieter Kern, Kirsten Peters, Ronald E. Unger, Roman Tsaryk, Harald Schmidt, Gunter Kamp and Prof. Dr. C. James KirkpatrickChapter 3 Topology?Dependent Cellular Interactions (pages 215–248): J. G. Barbara Nebe, Frank Luthen, Joachim Rychly, Eva Eisenbarth, Margit Muller, Stefan Winter, Dirk Velten, Frank Aubertin, Thomas K. Monsees, Richard H. W. Funk, Bettina Hoffmann, Frank Heidenau, Rainer Detsch, Gunter Ziegler, Tilo Pompe, Manuela Herklotz, Carsten Werner, Andrei P. Sommer, Rosemarie Fuhrmann and Ralf?Peter Franke Metallic Biomaterial Interfaces......Page 4 Contents......Page 8 Preface......Page 14 List of Contributors......Page 16 I Interface Influence of Materials and Surface Modification......Page 24 1 Introduction......Page 26 References......Page 27 2.1 Preparation of Titanium and Titanium Alloys......Page 28 2.2 Development of Wear-Resistant Nanocrystalline and Dispersion Strengthened Titanium Materials for Implants......Page 30 2.3 Amorphous Titanium–Silicon Alloys: New Materials for Implants......Page 34 References......Page 41 3.1 Patterning by Mechanical Treatment......Page 42 3.2.1 Bioactive Nanostructures......Page 46 3.2.2 Micro Structured Titanium Surfaces Produced by Chemical and Electrochemical Etching......Page 51 3.2.3 Enhanced Hydrophobicity Achieved by Etching and Coating......Page 53 3.3.2 Laser Direct Writing......Page 60 3.3.3 Surface Microprocessing of Titanium Films by Self-limited Oxidation......Page 64 3.4 Plasma Processes......Page 67 References......Page 70 4.1.1 Sol–Gel Coatings......Page 74 4.1.2 Anodic and Thermal Oxide Coatings......Page 88 4.2 Biomimetic Apatite Formation......Page 94 4.3 Surface Modification by Covalent and Noncovalent Attachment of Biomolecules......Page 104 4.3.1 Immobilization of RGD Peptides......Page 106 4.3.2 Improving the Biocompatibility of Titanium- and Cobalt-Based Biomaterials by Covalent Immobilization of Crosslinked Collagen......Page 111 4.3.3 Modifying Titanium Surfaces with Glycosaminoglycanes for Hemocompatibility......Page 115 4.3.4 Surface Modification of Titanium for Improvement of the Interfacial Biocompatibility......Page 125 4.3.5 Biofunctionalization of Titanium Substrates Using Maleic Anhydride Copolymer Films......Page 129 References......Page 133 II Physical and Physicochemical Surface Characterization......Page 140 1 Introduction......Page 142 2.1 Mechanical Characterization......Page 144 2.2 Optical Characterization......Page 148 2.3.1 DC Methods......Page 152 2.3.2 Impedance Spectroscopic Interface Characterization: Titanium in Contact with Electrolyte and Biosystem......Page 156 References......Page 163 3.1 Electronic Structure of the Interface......Page 166 3.2 Spectro-electrochemistry of the Surface......Page 171 References......Page 175 4 Physical Characterization of Protein Adsorption: Time-Resolved Determination of Protein Adsorption Using Quartz Crystal Microgravimetry with Dissipation Monitoring (QCM-D)......Page 176 References......Page 184 5 Computer Simulations: Modeling of Protein Adsorption on Nanostructured Metallic Surfaces......Page 186 References......Page 191 III Biological Characterization of the Interface and Materials-Related Biosystem Reactions......Page 194 1.1 Characterization of Surface-Dependent Protein Adsorption......Page 196 1.2.1 Hyaluronan-Mediated Adhesion......Page 202 1.2.2 Integrin-Mediated Adhesion on Nanostructures......Page 205 1.3 Surface Structure-Dependent Protein Expression in Adsorbed Cells......Page 207 References......Page 210 2.1.1 Influence of the Material Interface on Cell Migration......Page 214 2.1.2 Titanium–Cell Interface: Cell Biology and Growth Behavior......Page 219 2.2 Endothelial Cell-Specific Aspects in Biocompatibility Testing In Vitro......Page 227 References......Page 234 3.1 Cell Structure–Cell Function Dependence on Titanium Surfaces......Page 238 3.2.1 Cell Biological Response on Polished, Structured and Functionally Coated Titanium Alloys......Page 246 3.2.2 Effect of Nanostructures on Orientation and Physiology of Osteoblasts......Page 256 3.2.3 Cell Response to Ti6Al4V Modified with TiO(2) and RGDS Peptides on Different Surface Roughness......Page 260 3.2.4 Endothelial Cell Morphology on Functionalized Microstructured Titanium......Page 262 3.3 Resistivity of Cells Under Shear Load......Page 265 References......Page 268 Index......Page 272
With the decade-long desire for optimum performance using biomaterials without additional surgery, replacement or maintenance, a desperate search is underway for tailoring the physical and physico-chemical properties of the materials surface and the biosystem.
This is the first book to concentrate on the highly important area of metal-based implants and their improved functionality and acceptance by the body. It thus focuses on the properties of biomaterial-tissue interfaces, which are discussed in terms of the biomaterials and the specific biological environments they are used in. Strong emphasis is placed on the recent results and success in improving the interface characterization towards implant refinement.
From the contents:
I. Interface Influence of Materials and Surface Modifications
* Passivity-inducing and -retaining Surfaces
* Topological Surface Modifications
* Chemical Surface Modifications
II. Physical and Physicochemical Surface Characterization
* Surface Topology
* Electrochemical Characterization
* Spectroscopic Interface Characterization
* Physical Characterization of Protein Adsorption
III. Biological Characterization of the Interface and Materials Related Biosystem Reactions
* Protein and Cell Adhesion Mechanisms
* Material-induced Cell Interactions
* Topology-dependent Cellular Interactions
* Materials-dependent Formation of New Hard Tissue
Clearly divided into three sections on the interface influence of materials and surface modifications, the physical and physicochemical surface characterization, and the biological characterization of the interface and biosystem reactions, this book is the first to concentrate on the highly important area of metal-based implants and their improved functionality and acceptance by the body.
