Molecular imaging : principles and practice

Over the last decade, the field of molecular imaging of living subjects has evolved considerably and has seen spectacular advances in chemistry, engineering, and biomedical applications. In a relatively short period of time, comprehensive molecular imaging centres have been established in the US, Europe, and Asia and are increasingly integrated into basic sciences and translational networks. New investigators, collaborators, and students drawn into this multidisciplinary field have often expressed the desire and need for an authoritative textbook. This textbook was designed precisely to fill this need. Given the multidisciplinary nature of the field, the book is broken into six different sections. Part 1 (Molecular Imaging Technologies) summarises the different macro-, meso-, and microscopic imaging technologies currently available. Part 2 (Chemistry of Molecular Imaging) is dedicated to reviewing chemical approaches to imaging probe designs for different types of imaging technologies. This section also contains chapters on the emerging field of nanomaterials, chemical biology, and probe design as well as signal amplification strategies. Part 3 (Molecular Imaging in Cell and Molecular Biology) contains chapters dedicated to protein engineering, vectors, and pathways. Part 4 (Applications of Molecular Imaging) summarizes the above advances in different clinical disease entities. Part 5 (Molecular Imaging in Drug Evaluation) is dedicated to imaging in drug development. Part 6 provides chapters on computation, bioinformatics, and modelling. Pt. I. Molecular Imaging Technologies 1. Imaging Of Structure And Function With Pet/ct 2. Pet/mri 3. Spect And Spect/ct 4. Principles Of Micro X-ray Computed Tomography 5. Small Animal Spect, Spect/ct, And Spect/mri 6. Instrumentation And Methods To Combine Small Animal Pet With Other Imaging Modalities 7. Functional Imaging Using Bioluminescent Imaging 8. Optical Multimodality 9. Fiber Optic Fluorescence Imaging 10. Fluorescence Tomography 11. Endomicroscopy 12. Intravital Microscopy 13. Diffuse Optical Tomography 14. Ultrasound 15. Molecular Photoacoustic Tomography 16. Optical Projection Tomography 17. Signal Post Processing/image Reconstruction Pt. Ii. Chemistry Of Molecular Imaging 18. Chemistry Of Molecular Imaging. An Overview 19. Radiochemistry Of Pet 20. Radiochemistry Of Spect 21. Nanochemistry For Molecular Imaging 22. Newer Bioconjugation Methods 23. Targeted Antibodies And Peptides 24. Hyperpolarized 13c Magnetic Resonance Imaging? Principles And Applications 25.^ Mr Imaging Agents 26. Optical Imaging Agents 27. Ultrasound Contrast Agents 28. Multimodality Agents 29.?click Chemistry?. Applications To Molecular Imaging 30. The?one-bead-one-compound? Combinatorial Approach To Identifying Molecular Imaging Probes 31. Chemical Biology Approaches To Molecular Imaging 32. Theranostics. Agents For Diagnosis And Therapy 33. Magnetic Nanopt.icles 34. Fluorocarbon Agents For Quantitative Multimodal Molecular Imaging And Targeted Therapeutics 35. Aptamers For Molecular Imaging 36. Toxicology. Pt. Iii. Molecular Imaging In Cell & Molecular Biology 37. Overview Of Molecular And Cell Biology 38. Systems Biology 39. Protein Engineering 40. Phage Display For Agent Development 41. Molecular Imaging Of Gene Therapy 42. Developing Diagnostic And Therapeutic Viral Vectors 43. Cell Voyeurism Using Magnetic Resonance Imaging 44. Tumor Vasculature 45. Hypoxia Imaging 46. Protein-protein Interaction 47. Fluorescence Reporters/activatable Cell Penetrating Peptides 48.^ Imaging Of Signaling Pathways Pt. Iv. Applications Of Molecular Imaging 49. Molecular And Functional Imaging Of The Tumor Microenvironment 50. Novel Mr And Pet Imaging In The Rt Planning And Assessment Of Response Of Malignant Gliomas 51. Pet Diagnosis And Response Monitoring In Oncology 52. Mrs Treatment Response And Detection 53. Mri Treatment Response Assessment? Diffusion 54. Myocardial Metabolism 55. Congestive Heart Failure 56. Molecular Imaging Of Atherosclerosis 57. Thrombosis And Embolism 58. Molecular Imaging Of Stem Cells In Myocardial Infarction 59. Central Nervous System Molecular Imaging 60. Neuroreceptor Imaging 61. Neurodegeneration 62. Molecular Imaging Of Autoimmune Diseases 63. Rheumatoid Arthritis 64. Autoimmune Diabetes 65. Imaging In Asthma Pt. V. Molecular Imaging In Drug Evaluation 66. Molecular And Functional Imaging In Drug Development 67. Pet Imaging Clinical Trials 68. Mr Imaging In Clinical Trials 69. Imaging Of Gene Therapy. Basis And Clinical Trials Pt.^ Vi. Other 70. Visualization 71. Quantification Of Radiotracer Uptake Into Tissue 72. Mining High Throughput Data For Candidate Biomarkers As Imaging And Therapeutic Targets 73. Pharmacokinetic Modeling 74. Cost-effectiveness Analysis/economics Of Probe Development 75. Regulatory And Reimbursement Process For Imaging Agents And Devices. [edited By] Ralph Weissleder ... [et Al.]. Includes Bibliographical References And Index. Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals