Multiple Myeloma - An Overview

Multiple Myeloma Is A Malignant Disorder Characterized By The Proliferation Of Plasma Cells. Much Insight Has Been Gained Into The Molecular Pathways That Lead To Myeloma And Indeed Much More Remains To Be Done. The Understanding Of These Pathways Is Closely Linked To Their Therapeutic Implications And Is Stressed Upon In The Initial Chapters. Recently, The Introduction Of Newer Agents Such As Bortezomib, Lenalidomide, Thalidomide, Liposomal Doxorubicin, Etc. Has Led To A Flurry Of Trials Aimed At Testing Various Combinations In Order To Improve Survival. Higher Response Rates Observed With These Agents Have Led To Their Integration Into Induction Therapies. The Role Of Various New Therapies Vis A Vis Transplantation Has Also Been Examined. Recent Advances In The Management Of Plasmacytomas , Renal Dysfunction, Dentistry As Well As Mobilization Of Stem Cells In The Context Of Myeloma Have Also Found Exclusive Mention. Since Brevity Is The Soul Of Wit Our Attempt Has Been To Present Before The Reader A Comprehensive Yet Brief Text On This Important Subject. 00 preface_ Multiple Myeloma - An Overview......Page 1 Part 1_ Multiple Myeloma Disease Biology and it's Therapeutic Applications......Page 11 01_ Proteasome Inhibitors in the Treatment of Multiple Myeloma......Page 13 02_ Regulatory Cells and Multiple Myeloma......Page 43 03_ Effects of Recombinant Human Tumor Necrosis Factor-α and Its Combination with Native Human Leukocyte Interferon-α on P3-X63- Ag8.653 Mouse Myeloma Cell Growth......Page 71 04_ Cellular Immunotherapy Using Dendritic Cells Against Multiple Myeloma......Page 85 05_ Targeted Inhibition of Multiple Proinflammatory Signalling Pathways for the Prevention and Treatment of Multiple Myeloma......Page 103 06_ The SUMOylation Pathway as a Potential Therapeutic Target in Multiple Myeloma......Page 139 07_ Therapeutic Approaches for Targeting Hypoxia- Inducible Factor in Multiple Myeloma......Page 147 08_ The Contribution of Prognostic Factors to the Better Management of Multiple Myeloma Patients......Page 155 Part 2_ Multiple Myeloma Management Issues and Considerations......Page 185 09_ Solitary Plasmacytoma of Bone......Page 187 10_ Solitary Bone and Extramedullary Plasmacytoma......Page 195 11_ Multiple Myeloma and Dentistry......Page 217 12_ Renal Disease in Multiple Myeloma......Page 229 13_ Stem Cell Mobılızatıon in Multıple Myeloma......Page 251 14_ The Current Role of Stem Cell Transplantation in Multiple Myeloma......Page 273