Oncology and Basic Science (Orthopaedic Surgery Essentials Series)

This volume of our **Orthopaedic Surgery Essentials Series** presents all the information residents need during orthopaedic oncology rotations and the essential basic science needed for board preparation, clinical practice, and orthopaedic research, including molecular and cellular biology, growth and development, the genetic basis of musculoskeletal disorders, biomaterials and biologic response to orthopaedic implants, and neoplastic disorders. The book can easily be read cover to cover during a rotation or used for rapid review before boards or quick reference in clinical practice. The user-friendly, visually stimulating format features numerous tables and ample illustrations, including color plates showing tumor histopathology. Presents All The Information Residents Need During Orthopaedic Oncology Rotations And The Essential Basic Science Needed For Board Preparation, Clinical Practice, And Orthopaedic Research, Including Molecular And Cellular Biology, Growth And Development, The Genetic Basis Of Musculoskeletal Disorders, Biomaterials And Biologic Response To Orthopaedic Implants, And Neoplastic Disorders. The Book Can Easily Be Read Cover To Cover During A Rotation Or Used For Rapid Review Before Boards Or Quick Reference In Clinical Practice. The User-friendly, Visually Stimulating Format Features Numerous Tables And Ample Illustrations, Including Color Plates Showing Tumor Histopathology. Section I: Evaluation And Management Of Musculoskeletal Oncology Problems -- Evaluation Of Bone Tumors / Timothy A. Damron -- Evaluation Of Soft Tissue Tumors / Carol D. Morris -- Biopsy Of Musculoskeletal Tumors / Edward A. Athanasian -- Treatment Principles -- Surgical Margins / Robert Quinn -- Benign Tumors Of Bone / Cynthia M. Kelly -- Malignant Bone Lesions / Francis R. Patterson, Timoth A. Damron, And Carol D. Morris -- Soft Tissue Tumors / John Heiner And Jeremy White -- Pathologic Fractures / Timothy A. Damron. Section Ii: Specific Bone Neoplasms And Simulators -- Benign Bone Tumors -- Bone Lesions / Felasfa M. Wodajo -- Cartilage Lesions / Felasfa M. Wodajo -- Cystic Lesions / Sung Wook Seo, Young Lae Moon, And Francis Young-in Lee -- Myogenic, Lipogenic, And Neural Tumors / Sean V. Mcgarry And C. Parker Gibbs -- Fibrous Lesions Of Bone / Sung Wook Seo, Young Lae Moon, And Francis Young-in Lee -- Giant Cell Tumor Of Bone / Sean V. Mcgarry And C. Parker Gibbs -- Vascular Lesions / Sean V. Mcgarry And C. Parker Gibbs -- Other Tumors Of Undefined Neoplastic Nature / Sean V. Mcgarry And C. Parker Gibbs -- Bone Sarcomas -- Osteosarcoma / Francis R. Patterson -- Ewing Sarcoma And Primitive Neuroectodermal Tumor Of Bone / Bruce Rougraff -- Chondrosarcoma / R. Lor Randall And Kenneth J. Hunt -- Fibrous, Fibrohistiocytic, And Giant Cell Tumor Malignancies / Hannah D. Morgan -- Notochordal Tumors / Hannah D. Morgan -- Vascular Sarcomas Of Bone / Hannah D. Morgan -- Myogenic, Lipogenic, And Epithelial Bone Sarcomas / Hannah D. Morgan -- Congenital And Inherited Bone Conditions -- Familial Adenomatous Polyposis / Kathryn Palomino -- Beckwith-wiedemann Syndrome / Danielle A. Katz -- Skeletal Dysplasias / Danielle A. Katz -- Retinoblastoma Syndrome / Timothy A. Damron -- Rothmund-thomson Syndrome / Kathryn Palomino -- Werner Syndrome / Kathryn Palomino -- Metastatic Disease / Timothy A. Damron -- Hematologic Malignancies / Valerae O. Lewis -- Metabolic Bone Diseases / Susan V. Bukata. Section Iii: Specific Soft Tissue Neoplasms And Simulators -- Benign Soft Tissue Tumors / Timothy A. Damron And Gustavo De La Roza -- Soft Tissue Sarcomas / Carol D. Morris. Section Iv: Basic Science -- Cellular And Molecular Biology / Matthew J. Allen -- Growth And Development Of The Musculoskeletal System / Donald E. Sweet And Thomas V. Smallman -- Genetic Basis Of Musculoskeletal Disorders / Sathappan S. Sathappan, Kirill Ilalov, And Paul E. Di Cesare -- Biomechanics / Frederick W. Werner And Joseph A. Spadaro -- Biomaterials / Joseph A. Spadaro, Michael T. Clarke, And Julie M. Hasenwinkel -- Principles Of Orthopaedic Pharmacology / Carol D. Morris -- Bone Form, Function, Injury, Regeneration, And Repair / Alexia Hernandez-soria And Mathias Bostrom -- Articular Cartilage Structure, Composition, And Repair / Peter J. Roughley And Thomas V. Smallman -- Diarthrodial Joints / Thomas V. Smallman, Kris Shekitka, And Donald Flemming -- Meniscal Structure, Function, Repair, And Replacement / Mark C. Drakos And Answorth A. Allen -- Intervertebral Disk Structure, Composition, And Mechanical Function / Samuel A. Joseph, Jr., And Patrick Boland -- Tendon And Ligament Anatomy, Biology, And Biomechanics / Brian J. Harley And Joseph W. Bergman -- Peripheral Nerve Physiology, Anatomy, And Pathology / Shikha Sethi ... [et Al.] -- Skeletal Muscle Anatomy, Physiology, And Mechanics / Bryan T. Kelly And William J. Robertson -- Infectious Disorders Of Bone And Joint / Thomas V. Smallman ... [et Al.] -- Bacterial Infection -- Granulomatous Infection -- Infection Associated With Neuropathy -- Viral Disorders -- Neoplasia / Matthew J. Allen. Book Editor, Timothy A. Damron. Includes Bibliographical References And Index. ONCOLOGY AND BASIC SCIENCE 3 CONTENTS 7 CONTRIBUTING AUTHORS 11 SERIES PREFACE 15 PREFACE 17 ACKNOWLEDGMENTS 19 SECTION I EVALUATION AND MANAGEMENT OF MUSCULOSKELETAL ONCOLOGY PROBLEMS 21 EVALUATION OF BONE TUMORS 23 EVALUATION OF SOFT TISSUE TUMORS 48 BIOPSY OF MUSCULOSKELETAL TUMORS 57 TREATMENT PRINCIPLES 70 SURGICAL MARGINS 70 BENIGN TUMORS OF BONE 74 MALIGNANT BONE LESIONS 80 SOFT TISSUE TUMORS 107 PATHOLOGIC FRACTURES 112 SECTION II SPECIFIC BONE NEOPLASMS AND SIMULATORS 135 BENIGN BONE TUMORS 137 BONE LESIONS 137 CARTILAGE LESIONS 146 CYSTIC LESIONS 160 MYOGENIC, LIPOGENIC, AND NEURAL TUMORS 167 FIBROUS LESIONS OF BONE 169 GIANT CELL TUMOR OF BONE 179 VASCULAR LESIONS 184 OTHER TUMORS OF UNDEFINED NEOPLASTIC NATURE 190 BONE SARCOMAS 197 OSTEOSARCOMA 197 EWING SARCOMA AND PRIMITIVE NEUROECTODERMAL TUMOR OF BONE 207 CHONDROSARCOMA 212 FIBROUS, FIBROHISTIOCYTIC, AND GIANT CELL TUMOR MALIGNANCIES 221 NOTOCHORDAL TUMORS 224 VASCULAR SARCOMAS OF BONE 226 MYOGENIC, LIPOGENIC, AND EPITHELIAL BONE SARCOMAS 229 CONGENITAL AND INHERITED BONE CONDITIONS 232 FAMILIAL ADENOMATOUS POLYPOSIS 232 BECKWITH-WIEDEMANN SYNDROME 234 SKELETAL DYSPLASIAS 235 RETINOBLASTOMA SYNDROME 244 ROTHMUND-THOMSON SYNDROME 246 WERNER SYNDROME 247 METASTATIC DISEASE 249 HEMATOLOGIC MALIGNANCIES 264 METABOLIC BONE DISEASES 271 SECTION III SPECIFIC SOFT TISSUE NEOPLASMS AND SIMULATORS 281 BENIGN SOFT TISSUE TUMORS 283 SOFT TISSUE SARCOMAS 314 SECTION IV BASIC SCIENCE 327 CELLULAR AND MOLECULAR BIOLOGY 329 GROWTH AND DEVELOPMENT OF THE MUSCULOSKELETAL SYSTEM 341 GENETIC BASIS OF MUSCULOSKELETAL DISORDERS 367 BIOMECHANICS 387 BIOMATERIALS 393 PRINCIPLES OF ORTHOPAEDIC PHARMACOLOGY 407 BONE FORM, FUNCTION, INJURY, REGENERATION, AND REPAIR 413 ARTICULAR CARTILAGE STRUCTURE, COMPOSITION, AND REPAIR 425 DIARTHRODIAL JOINTS 438 MENISCAL STRUCTURE, FUNCTION, REPAIR, AND REPLACEMENT 463 INTERVERTEBRAL DISC STRUCTURE, COMPOSITION, AND MECHANICAL FUNCTION 472 TENDON AND LIGAMENT ANATOMY, BIOLOGY, AND BIOMECHANICS 483 PERIPHERAL NERVE PHYSIOLOGY, ANATOMY, AND PATHOLOGY 494 SKELETAL MUSCLE ANATOMY, PHYSIOLOGY, AND MECHANICS 504 INFECTIOUS DISORDERS OF BONE AND JOINT 515 BACTERIAL INFECTION 516 GRANULOMATOUS INFECTION 528 INFECTION ASSOCIATED WITH NEUROPATHY 541 VIRAL DISORDERS 544 NEOPLASIA 545 INDEX 553