سم‌زدایی شنوایی

'Ototoxicity' is a compendium of information on the ototoxic potential of clinically useful drugs. Each section of this thorough text is written by a leading authority in the field. The book reviews the important classes of medications known to cause ototoxicity and their mechanisms. Clinical manifestations, what is known about pathophysiology, strategies for prevention and treatment, and medical-legal issues for each class of compounds are reviewed. Auditory and vestibular monitoring and new therapeutic strategies that may prevent or minimize ototoxicity are highlighted in addition to discussing recent advances in protective therapy. Also included is the therapeutic use of the ototoxic properties of aminoglycosides in the clinical treatment of inner ear dysfunction. OTOTOXICITY......Page 4 Copyright......Page 5 Dedication......Page 6 Contents......Page 8 Preface......Page 10 List of Contributors......Page 12 Ch01: Anatomy and Physiology of the Cochlea......Page 14 Ch02: Physiology of the Vestibular System......Page 33 Ch03: Salicylates, Nonsteroidal Anti-inflammatory Drugs, Quinine, and Heavy Metals......Page 41 Ch04: Ototoxicity of Loop Diuretics......Page 55 Ch05: Cinical Uses of Cisplatin......Page 63 Ch06: Ototoxicity of Platinum Compounds......Page 73 Ch07: Iron Chelating and Other Chemotherapeutic Agents: The Vinca Alkaloids......Page 89 Ch08: Clinical Aminoglycoside Ototoxicity......Page 95 Ch09: Mechanisms for Aminoglycoside Ototoxicity: Basic Science Research......Page 106 Ch10: Macrolides......Page 114 Ch11: Middle Ear Effects of Ototopical Agents......Page 120 Ch12: Topical Aminoglycoside Cochlear Toxicity......Page 127 Ch13: Topical Aminoglycoside Vestibular Toxicity......Page 134 Ch14: Chloramphenicol, Colymycin, and Polymyxin......Page 141 Ch15: Topical Antifungals......Page 147 Ch16: Surgical Disinfectants and Antiseptics......Page 153 Ch17: Genetic Factors in Aminoglycoside Ototoxicity......Page 157 Ch18: Audiologic Monitoring for Ototoxicity......Page 166 Ch19: Monitoring Vestibular Ototoxicity......Page 174 Ch20: Ototoxic Damage to Hearing: Otoprotective Therapies......Page 183 Ch21: Systemic Treatment of Bilateral Meniere’s Disease......Page 197 Ch22: Intratympanic Gentamicin in the Treatment of Meniere’s Disease......Page 204 Ch23: Medicolegal Aspects of Ototoxicity......Page 211 Appendix 1: Information Provided to Lawyers.......Page 220 Appendix 2: Summary of the 2004 AAO-HNS Consensus Panel Recommendations......Page 226 Appendix 3: Major Groups of Agents Recognized to be Ototoxic in Humans......Page 227 Index......Page 228 Roland (otolaryngology, head and neck surgery, U. of Texas Southwestern Medical Center at Dallas, US), Rutka (otolaryngology, U. of Toronto, Canada) and their colleagues review the major medical aspects of the functional impairment and cellular damage to the tissues of the inner ear caused by certain substances, a number of which are used in various medical applications. The 23 chapters begin with anatomy and physiology and then review the toxicity of such substances as loop diuretic, cisplatin, platinum compounds, iron chelating and other chemotherapeutic agents, aminoglycoside, and macrolides. The topical toxic effects of ototopical agents, aminoglycoside, antifungals, surgical disinfectants and antiseptics, and other substances are then examined. Later chapters discuss genetic factors in aminoglycoside ototoxicity, audiologic monitoring, ototoxic damage to hearing and therapies, treatment of Meniere's disease, and medicolegal aspects. The included CD-ROM contains the text and illustrations from the book in searchable electronic form (PDF). Annotation © 2006 Book News, Inc., Portland, OR "This original text on ototoxicity belongs in the hands of every doctor who prescribes certain systemic or topical drugs - such as the aminoglycosides - and everyone who sees patients with ear disorders." "Written by experts in the field, the text reviews all classes of medication known to cause functional impairment and cellular damage to the tissues of the middle ear - especially the end organs of the cochlear and vestibular divisions of the eight cranial nerves. The text opens with basic anatomy and physiology and continues with clinical manifestations of ototoxicity, pathophysiology, prevention, and treatment, and medical-legal issues for each class of compounds. Case presentations, followed by discussion, illustrate key medicolegal concepts."--Jacket