Part B: Numerical Computer Methods

The contributions in this volume emphasize numerical analysis of experimental data and analytical biochemistry, with examples taken from biochemistry. They serve to inform biomedical researchers of the modern data analysis methods that have developed concmitantly with computer hardware Content: Contributors to volume 240 Pages ix-x Preface Pages xi-xiii Michael L. Johnson, Ludwig Brand Volumes in series Pages xv-xxviii [1] Use of least-squares techniques in biochemistry Original Research Article Pages 1-22 Michael L. Johnson [2] Parameter estimates from nonlinear models Original Research Article Pages 23-36 Donald G. Watts [3] Effects of heteroscedasticity and skewness on prediction in regression: Modeling growth of the human heart Original Research Article Pages 37-51 Robert D. Abbott, Howard P. Gutgesell [4] Artifacts of fourier series analysis Original Research Article Pages 51-68 Michael L. Johnson, Michelle Lampl [5] Quantification of evolution from order to randomness in practical time series analysis Original Research Article Pages 68-89 Steven M. Pincus [6] Sequential versus simultaneous analysis of data: Differences in reliability of derived quantitative conclusions Original Research Article Pages 89-121 Martin Straume [7] Model-independent quantification of measurement error: Empirical estimation of discrete variance function profiles based on standard curves Original Research Article Pages 121-150 Martin Straume, Johannes D. Veldhuis, Michael L. Johnson [8] Impact of variance function estimation in regression and calibration Original Research Article Pages 150-170 Lie-Ju Hwang [9] Application of the Kalman filter to computational problems in statistics Original Research Article Pages 171-181 Emery N. Brown, Christopher H. Schmid [10] Modeling chemical reactions: Jacobian paradigm and related issues Original Research Article Pages 181-198 Richard I. Shrager [11] The mathematics of biological oscillators Original Research Article Pages 198-216 G. Bard Ermentrout [12] Diffusion-modulated energy transfer and quenching: Analysis by numerical integration of diffusion equation in laplace space Original Research Article Pages 216-262 JГіzef KuЕ›ba, Joseph R. Lakowicz [13] Maximum entropy method of data analysis in time-resolved spectroscopy Original Research Article Pages 262-311 Jean-Claude Brochon [14] Analysis of kinetic data: Practical applications of computer simulation and fitting programs Original Research Article Pages 311-322 Carl Frieden [15] Determination of rate and equilibrium binding constants for macromolecular interactions by surface plasmon resonance Original Research Article Pages 323-349 Daniel J. O'Shannessy, Michael Brigham-Burke, K. Karl Soneson, Preston Hensley, Ian Brooks [16] Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins Original Research Article Pages 349-377 Johannes D. Veldhuis, Lindsay M. Faunt, Michael L. Johnson [17] Testing pulse detection algorithms with simulations of episodically pulsatile substrate, metabolite, or hormone release Original Research Article Pages 377-415 Johannes D. Veldhuis, Michael L. Johnson [18] Error analysis of macromolecular structures determined with nuclear magnetic resonance data Original Research Article Pages 415-438 John W. Shriver, Stephen Edmondson [19] Characterization of enzyme-complex formation by analysis of nuclear magnetic resonance line shapes Original Research Article Pages 438-446 Carol Beth Post [20] Computer simulations of nuclear overhauser effect spectra of complex oligosaccharides Original Research Article Pages 446-459 C. Allen Bush [21] Determining confidence intervals for parameters derived from analysis of equilibrium analytical ultracentrifugation data Original Research Article Pages 459-478 Ian Brooks, Donald G. Watts, K. Karl Soneson, Preston Hensley [22] Boundary analysis in sedimentation velocity experiments Original Research Article Pages 478-501 Walter F. Stafford III [23] Statistical thermodynamic analysis of differential scanning calorimetry data: Structural deconvolution of heat capacity function of proteins Original Research Article Pages 502-530 Ernesto Freire [24] Analysis of two-dimensional differential scanning calorimetry data: Elucidation of complex biomolecular energetics Original Research Article Pages 530-568 Martin Straume [25] Monte Carlo simulations of membranes: Phase transition of small unilamellar dipalmitoylphosphatidylcholine vesicles Original Research Article Pages 569-593 IstvГЎn P. SugГЎr, Rodney L. Biltonen, Neil Mitchard [26] Analysis of drug-DNA binding isotherms: A Monte Carlo approach Original Research Article Pages 593-614 John J. Correia, Jonathan B. Chaires [27] Analysis of multidimensional spectroscopic data to monitor unfolding of proteins Original Research Article Pages 615-645 Glen D. Ramsay, Maurice R. Eftink [28] Estimating binding constants for site-specific interactions between monovalent ions and proteins Original Research Article Pages 645-667 Bertrand GarcГ­a-Moreno E [29] Pattern recognition metric for comparison of protein structures based on amino acid sequences Original Research Article Pages 667-723 John A. Schetz [30] Fluorescence lifetime imaging microscopy: Homodyne technique using high-speed gated image intensifier Original Research Article Pages 723-748 Henryk Szmacinski, Joseph R. Lakowicz, Michael L. Johnson [31] Computations of time-dependent photon migration for biomedical optical imaging Original Research Article Pages 748-781 Eva M. Sevick-Muraca [32] Applying bifurcation theory to enzyme kinetics Original Research Article Pages 781-816 Craig G. Hocker Author index Pages 817-840 Subject index Pages 841-857