Peptides: "Design, Synthesis, And Biological Activity"

A successful seientific career requires constant effort on the part of the seientist. If such a career is to be achieved by seientists in developing countries where the faeilities are not easily available, even more dedication is required. Dr. K. M. Sivanandaiah, having completed a successful career in the field of peptide chemistry, is such a seientist. Being weIl aware of the limited research facilities available in India, we are extraordinarily appreciative of Professor Sivanandaiah's dedication to the advancement of science. As a Professor of Chemistry and, until his retirement in 1992, the Head of the Department of Studies in Chemistry at Bangalore University, India, he not only devoted much of his time to his students, teaching basic organic chemistry, but was also able to contribute to the field of peptide chemistry. After completing 25 years of service at Central College, Bangalore, where he was admired as an outstanding teacher, Professor Sivanandaiah is still active in research. He is now Professor Emeritus and continues to contribute to the field of peptides. As former students of Professor Sivanandaiah, we felt that publishing a book containing articles related to the design, synthesis, conformation, and biological activity of peptides and written by eminent scientists in the field of peptide research would be a fitting tribute to his role in the field of bioorganic chemistry. Front Matter....Pages i-xiv K. M. Sivanandaiah: Twenty-Five Years of Peptide Research in Central College, Bangalore University, Bangalore, India....Pages 1-8 Front Matter....Pages 9-9 Catalytic Transfer Hydrogenation and Hydrogenolysis by Formic Acid and its Salts....Pages 11-26 Syntheses of Natriuretic Peptides Using a New S -Protecting Group, S -Trimethylacetamidomethyl (Tacm) Group....Pages 27-37 Solid-Phase Synthesis of Cyclic Peptides....Pages 39-58 Enzymatic Semisynthesis of Growth Hormone-Releasing Factor and Potent Analogs....Pages 59-68 Recent Developments in the Synthesis of Glycopeptides....Pages 69-77 Front Matter....Pages 79-79 Synthesis, Characterizations, and Medical Applications of Bioelastic Materials....Pages 81-111 Synthetic Peptides in the Study of Viral Fusion, Inflammation, and Atherosclerosis....Pages 113-132 “De Novo” Engineering of Peptide Immunogenic and Antigenic Determinants as Potential Vaccines....Pages 133-164 Complementary Peptides: Applications of the Molecular Recognition Theory to Peptide and Protein Purification and Design....Pages 165-179 Conformational Studies on Model Peptides and Peptidomimetics....Pages 181-196 Front Matter....Pages 197-197 The Design and Synthesis of Long-Acting Oxytocin Antagonists Substituted in Positions 2, 7, and 8....Pages 199-208 Calcitonin: A Minireview....Pages 209-221 Importance of Ca 2+ -Hormone Interaction in Conformation-Activity Correlations....Pages 223-234 Front Matter....Pages 235-235 The Binding of Peptides and Proteins to Membranes Containing Anionic Lipid....Pages 237-249 Synthetic Peptides Mimic the Active Sites of Fibronectin Receptors from Gram-Positive Bacteria....Pages 251-257 Analyses of Various Folding Patterns of the HIV-1 Loop....Pages 259-277 Regulation of Human Immunodeficiency Virus Gene Expression by the Tat and Rev Proteins....Pages 279-300 Back Matter....Pages 301-313