Perspectives in Basic and Applied Toxicology features a collection of essays on various aspects of toxicology. It aims to relate fundamental knowledge of toxicology to its application in assessing relevance of that information to the causation of adverse health effects, predicting hazardous situations, defining protective and precautionary measures, and the recognition and management of intoxication in humans. Another objective of this volume is to encourage those with responsibility for the training of toxicologists to instill a greater concern about ethical and moral issues as fundamental to the practice of toxicology as a profession with wide-ranging social implications. This book is organized into 14 chapters. The coverage of these chapters include assessment of chemical hazards in the workplace, the relation between animal studies and epidemiology in the context of industrial toxicology, carcinogenicity testing in animals, and biochemical evaluation of neurotoxicity. This book will be of interest to undergraduate and graduate toxicologists, pharmacologists, physicians, industrial hygienists, and other health professionals. Content: Front Matter , Page iii Copyright , Page iv Preface , Pages v-viii , Bryan Ballantyne Contributors , Pages ix-x Chapter 1 - Biochemical Methods for Assessment of Neurotoxicity , Pages 1-30 , Mohamed B. Abou-Donia, Daniel M. Lapadula, Clark D. Carrington Chapter 2 - Chemical Excitants of Cutaneous Pain , Pages 31-41 , A.G. Ramage Chapter 3 - Ototoxicity: Morphological and Functional Correlations between Experimental and Clinical Studies , Pages 42-69 , E.S. Harpur Chapter 4 - Xenobiotic-Induced Rhabdomyolysis , Pages 70-153 , Bryan Ballantyne Chapter 5 - Drug-induced Oesophagitis , Pages 154-160 , David B. Doman Chapter 6 - Review of Recent Advances in the Development and Application of the Micronucleus Test System , Pages 161-198 , R.S. Slesinski, P.J. Guzzie Chapter 7 - Chemical Induction of Dominant Lethal Mutations in Mammals , Pages 199-205 , A. Philip Leber Chapter 8 - Developmental Toxicity in Toxicologic Research and Testing , Pages 206-241 , Rochelle W. Tyl Chapter 9 - The Role of Genetic Differences as a Determinant in Xenobiotic-Induced Developmental Toxicity , Pages 242-255 , George H. Lambert Chapter 10 - A Survey of in vitro Teratology Tests , Pages 256-267 , John A. Thomas, Yigal Greener Chapter 11 - Carcinogenicity Tests in Animals: Some Pitfalls That Could Be Avoided , Pages 268-284 , Paul Grasso Chapter 12 - Experimental Approaches to the Design and Assessment of Antidotal Procedures , Pages 285-308 , Timothy C. Marrs Chapter 13 - The Interaction between Epidemiology and Animal Studies in Industrial Toxicology , Pages 309-329 , H. Michael, D. Utidjian Chapter 14 - Practical Assessment and Communication of Chemical Hazards in the Workplace , Pages 330-378 , Tipton R. Tyler, Bryan Ballantyne Index , Pages 379-393
