Pharmaceutical Pelletization Technology

Filling a void in the literature, this important book addresses the technology of pelletization from the pharmaceutical industry point of view. Contributors are internationally recognized academicians, industrial scientists, and engineers working for leading pharmaceutical companies such as Warner-Lambert and Bristol-Myers. Providing detailed discussion of both the “whys” and “hows” of developing pelletized dosage forms, Pharmaceutical Pelletization Technology describes the most popular pelletization processes pertinent to the pharmaceutical industry ... covers in detail design features of the most widely used processing equipment—and lists equipment suppliers ... discusses variables that must be critically evaluated prior to the development of pellet formulations ... addresses physical and mechanical forces that govern pellet formation and growth ... and reviews current techniques used to evaluate and characterize pellets. An excellent formulation and processing guide, this exemplary reference is must reading for pharmaceutical formulation scientists, technologists, and researchers; manufacturing and industrial pharmacists/scientists; clinical and medicinal chemists; biotechnologists; and others involved in the formulation, manufacture, or regulation of pharmaceutical dosage form design. Cover Half Title Series Title Copyright Preface Contents Contributors 1. Pellets: A General Overview 2. Conventional and Specialized Coating Pans 3. Fluid Bed Equipment 4. Extrusion and Spheronizing Equipment 5. Centrifugal Equipment 6. Mechanism of Pellet Formation and Growth 7. Solution and Suspension Layering 8. Dry Powder Layering 9. Extrusion and Spheronization Technology 10. Formulation Variables 11. Evaluation and Characterization of Pellets Index This book serves as a formulation and processing guide during the development of pelletized dosage forms. It provides the pharmaceutical technologist with basic information about the design aspects of the relevant processing equipment.