Pharmacokinetics and toxicokinetics

Pharmacokinetics and Toxicokinetics provides an overview of pharmacokinetics and toxicokinetics in a comprehensible, interrelated, and applied manner. It integrates the principles held in common by both fields through a logical and systematic approach. The book presents mathematical descriptions of physiological processes employed in different appr Chapter 1. The influence of routes of administration on ADME -- chapter 2. Mechanisms of absorption and permeation of xenobiotics -- chapter 3. In Vivo distribution of xenobiotics -- chapter 4. Elimination rate, clearance, and the theoretical models -- chapter 5. Renal excretion of xenobiotics and estimation of related PK/TK parameters and constants -- chapter 6. Biotransformation of xenobiotics -- chapter 7. Kinetics of In Vitro metabolism : assimilation of intrinsic clearance in hepatic clearance -- chapter 8. Pharmaceutical, biopharmaceutical, and physiological factors influencing oral absorption : mechanistic absorption models -- chapter 9. Mathematical modeling in pharmacokinetics and toxicokinetics -- chapter 10. PK/TK analysis of instantaneous exposure to xenobiotics (single bolus injection) -- chapter 11. PK/TK analysis of continuous zero-order exposure to xenobiotics (intravenous infusion) -- chapter 12. PK/TK analysis of xenobiotics absorbed via an extravascular route of administration (oral administration) -- chapter 13. PK/TK of xenobiotics absorbed through the skin (transdermal absorption) -- chapter 14. PK/TK analysis of multiple dosing -- chapter 15. Bioavailability, bioequivalence, and biosimilar evaluations -- chapter 16. Preclinical PK/TK and clinical trials -- chapter 17. Population pharmacokinetics/toxicokinetics -- chapter 18. Quantitative extrapolation interspecies scaling/low dose extrapolation The Influence of Routes of Administration on ADMEIntroductionPharmacokinetics (PK) and Pharmacodynamics (PD)Toxicokinetics (TK) and Toxicodynamics (TD)Concepts Basic to PK and TKInfluence of Routes of Exposure/Administration on PK/TK analysisBiomarkersReferencesMechanisms of Absorption and Permeation of XenobioticsIntroductionPassive DiffusionCarrier-Mediated Transcellular DiffusionTranscellular Diffusion Subject to P-Glycoprotein EffluxActive TransportEndocytosis and PinocytosisSolvent Drag, Osmosis, and Two-Pore TheoryIon-Pair AbsorptionReferencesIn Vivo Distribution of XenobioticsIntroducti Front Cover; Contents; Preface; Chapter 1: The Influence of Routes of Administration on ADME; Chapter 2: Mechanisms of Absorption and Permeation of Xenobiotics; Chapter 3: In Vivo Distribution of Xenobiotics; Chapter 4: Elimination Rate, Clearance, and the Theoretical Models; Chapter 5: Renal Excretion of Xenobiotics and Estimation of Related PK/TK Parameters and Constants; Chapter 6: Biotransformation of Xenobiotics; Chapter 7: Kinetics of in Vitro Metabolism : Assimilation of Intrinsic Clearance in Hepatic Clearance