Platelet-activating factor and structurally related alkyl ether lipids

Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids......Page 1 PREFACE......Page 3 Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids......Page 4 OPENING REMARKS......Page 5 Contents......Page 6 Platelet-Activating Factor PAF: An Introduction......Page 14 REFERENCES......Page 15 Studies on the Selectivity of Enzymes Involved in Platelet- Activating Factor Formation in Stimulated Cells......Page 16 RESULTS AND DISCUSSION......Page 17 REFERENCES......Page 22 MATERIALS AND METHODS......Page 23 RESULTS AND DISCUSSION......Page 24 REFERENCES......Page 27 Platelet-Activating Factor Acetylhydrolase Activity in Human Tissues and Blood Cells......Page 28 RESULTS......Page 29 REFERENCES......Page 33 MATERIALS AND METHODS......Page 35 RESULTS......Page 36 DISCUSSION......Page 38 REFERENCES......Page 40 MATERIALS AND METHODS......Page 41 RESULTS AND DISCUSSION......Page 42 REFERENCES......Page 45 MATERIALS AND METHODS......Page 46 RESULTS......Page 47 DISCUSSION......Page 51 REFERENCES......Page 52 EXPERIMENTAL PROCEDURES......Page 53 RESULTS AND DISCUSSION......Page 54 REFERENCES......Page 59 MATERIALS AND METHODS......Page 60 RESULTS......Page 61 DISCUSSION......Page 62 REFERENCES......Page 63 The Hormonal Regulation of Platelet-Activating Factor Acetylhydrolase Activity in Plasma......Page 64 RESULTS......Page 65 DISCUSSION......Page 68 REFERENCES......Page 69 ROLE FOR ARACHIDONATE IN THE CATABOLISM OF PAF......Page 70 THE ROLE OF ARACHIDONIC ACID IN THE BIOSYNTHESIS OF PAF......Page 71 PHOSPHOLIPID SOURCES OF ARACHIDONIC ACID USED FOR EICOSANOID BIOSYNTHESIS AND THEIR RELATIONSHIP TO PAF SOURCES......Page 73 COMMON REGULATORY MECHANISM FOR PAF AND ARACHIDONIC ACID......Page 74 SUMMARY AND FUTURE DIRECTIONS......Page 75 REFERENCES......Page 76 PAF STIMULATED PHOSPHOINOSITIDE TURNOVER......Page 77 PHARMACOLOGICAL MANIPULATIONS......Page 78 SIGNIFICANCE OF PPI TURNOVER IN PAF RESPONSES......Page 80 REFERENCES......Page 81 TRANSMEMBRANE SIGNALLING AND ACETYLTRANSFERASE ACTIVATION......Page 83 ACKNOWLEDGMENT......Page 85 REFERENCES......Page 86 PAF Effects on Transmembrane Signaling Pathways in Rat Kupffer Cells......Page 87 MATERIALS AND METHODS......Page 88 RESULTS AND DISCUSSION......Page 89 REFERENCES......Page 92 MATERIALS AND METHODS......Page 93 RESULTS......Page 94 DISCUSSION......Page 96 REFERENCES......Page 98 MATERIALS AND METHODS......Page 99 RESULTS......Page 100 DISCUSSION......Page 101 REFERENCES......Page 102 MATERIALS AND METHODS......Page 103 RESULTS......Page 104 DISCUSSION......Page 107 REFERENCES......Page 108 MATERIALS AND METHODS......Page 109 RESULTS......Page 110 REFERENCES......Page 112 MATERIALS AND METHODS......Page 114 RESULTS......Page 115 DISCUSSION......Page 117 REFERENCES......Page 118 Effect of Platelet-Activating Factor on Tumor Necrosis Factor-Induced Superoxide Generation from Human Neutrophils. Possible Involvement of G Proteins......Page 120 RESULTS......Page 121 DISCUSSION......Page 123 REFERENCES......Page 124 MATERIALS AND METHODS......Page 125 RESULTS AND DISCUSSION......Page 126 REFERENCES......Page 128 MATERIALS AND METHODS......Page 129 RESULTS......Page 130 DISCUSSION......Page 133 REFERENCES......Page 134 PLANT CELL CULTURES......Page 135 BIOTRANSFORMATION OF ALKYLGLYCEROLS IN PLANT CELL CULTURES......Page 136 SEMISYNTHESIS OF ALKYLGLYCEROPHOSPHOCHOLINES I,III AND ALKYLACETYLGLYCEROPHOSPHOCHOLINES II,IV......Page 138 SEMISYNTHESIS OF ALKYLACYLGLYCEROPHOSPHO- N-ACYLETHANOLAMINES V......Page 139 REFERENCES......Page 140 REFERENCES......Page 142 MATERIALS AND METHODS......Page 144 RESULTS AND DISCUSSION......Page 147 REFERENCES......Page 150 MATERIALS AND METHODS......Page 151 RESULTS......Page 152 DISCUSSION......Page 153 REFERENCES......Page 155 MATERIALS AND METHODS......Page 157 RESULTS AND DISCUSSION......Page 158 REFERENCES......Page 160 Tandem Mass Spectrometry of Negative Ions from Choline Phospholipid Molecular Species Related to Platelet Activating Factor......Page 161 RESULTS AND DISCUSSION......Page 162 REFERENCES......Page 165 MATERIALS AND METHODS......Page 166 RESULTS AND DISCUSSION......Page 167 REFERENCES......Page 169 MATERIALS AND METHODS......Page 171 RESULTS......Page 172 DISCUSSION......Page 173 REFERENCES......Page 174 MATERIALS AND METHODS......Page 175 RESULTS......Page 176 DISCUSSION......Page 177 REFERENCES......Page 178 MATERIALS AND METHODS......Page 179 RESULTS......Page 180 DISCUSSION......Page 182 REFERENCES......Page 184 MATERIALS AND METHODS......Page 185 RESULTS AND DISCUSSION......Page 186 REFERENCES......Page 188 MATERIALS AND METHODS......Page 189 RESULTS AND DISCUSSION......Page 190 REFERENCES......Page 192 MATERIALS AND METHODS......Page 193 RESULTS......Page 194 REFERENCES......Page 195 L-659,989: A Useful Probe in the Detection of Multiple Conformational States of PAF Receptors......Page 197 REFERENCES......Page 202 STRUCTURE-ACTIVITY RELATIONSHIP OF LIGNAN ANALOGS......Page 203 PAF ANTAGONISTS WITH DUAL ACTIONS......Page 204 REFERENCES......Page 205 DISSOCIATION OF CNS AND ANTI-PAF ACTIVITY......Page 206 SYNTHESIS OF NEW COMPOUNDS: WEB 2086......Page 207 STRUCTURE ACTIVITY RELATIONSHIP......Page 208 REFERENCES......Page 209 3-D ELECTROSTATIC MAPS OF SELECTED PAF ANTAGONISTS: THE “CACHE-OREILLES? EFFECT......Page 211 CONCLUSION......Page 213 REFERENCES......Page 214 MATERIALS AND METHODS......Page 216 RESULTS AND DISCUSSION......Page 219 REFERENCES......Page 220 MATERIALS AND METHODS......Page 221 RESULTS AND DISCUSSION......Page 222 REFERENCES......Page 223 MATERIALS AND METHODS......Page 224 RESULTS......Page 225 DISCUSSION......Page 226 REFERENCES......Page 227 MATERIALS AND METHODS......Page 228 RESULTS......Page 229 REFERENCES......Page 232 PAF BIOSYNTHESIS, METABOLISM, AND MECHANISMS OF ACTION......Page 233 MECHANISMS OF ACTION......Page 234 CONCLUSION......Page 235 REFERENCES......Page 236 MATERIALS AND METHODS......Page 238 DISCUSSION......Page 239 REFERENCES......Page 241 MATERIALS AND METHODS......Page 242 RESULTS......Page 243 DISCUSSION......Page 247 REFERENCES......Page 248 MATERIALS AND METHODS......Page 249 RESULTS AND DISCUSSION......Page 250 REFERENCES......Page 251 MATERIALS AND METHODS......Page 253 RESULTS......Page 254 REFERENCES......Page 256 MATERIALS AND METHODS......Page 258 RESULTS......Page 259 DISCUSSION......Page 261 REFERENCES......Page 262 MATERIALS AND METHODS......Page 263 RESULTS......Page 264 REFERENCES......Page 265 Calcium Channel Blockade Inhibits Platelet Activating Factor Production by Human Umbilical Vein Endothelial Cells......Page 267 RESULTS......Page 268 DISCUSSION......Page 269 ACKNOWLEDGMENTS......Page 270 REFERENCES......Page 271 MATERIALS AND METHODS......Page 272 RESULTS......Page 273 DISCUSSION......Page 274 REFERENCES......Page 275 MATERIALS AND METHODS......Page 276 DISCUSSION......Page 277 REFERENCES......Page 278 MATERIAL AND METHODS......Page 280 RESULTS......Page 281 DISCUSSION......Page 283 REFERENCES......Page 284 Platelet-Activating Factor and Polyunsaturated Fatty Acids in Cerebral Ischemia or Convulsions: Intracellular PAF-Binding Sites and Activation of a Fos/Jun/AP-1 Transcriptional Signaling System......Page 285 EFFECTS OF PAF ANTAGONISTS ON CEREBRAL BLOOD FLOW AND ON ENDOGENOUS FREE PUFA DURING ISCHEMIA OR CONVULSIONS......Page 286 IMMEDIATE-EARLY GENES......Page 288 PAF ACTIVATES TRANSCRIPTION OF C-FOS AND C-JUN......Page 289 REFERENCES......Page 290 MATERIALS AND METHODS......Page 292 RESULTS AND DISCUSSION......Page 293 REFERENCES......Page 294 RESULTS AND DISCUSSION......Page 296 REFERENCES......Page 298 Cardiovascular Effects of Platelet-Activating Factor......Page 299 HEMODYNAMIC CHANGES DURING PAF-INDUCED CIRCULATORY COLLAPSE......Page 300 HEMODYNAMIC EFFECTS OF PAF-RELATED INTERVENTIONS......Page 301 EFFECTS OF MORE PROLONGED EXPOSURE TO PAF......Page 302 PAF INHIBITION RESULTING FROM BLOCKADE OF TxA2......Page 303 CONCLUSIONS......Page 304 REFERENCES......Page 305 CARDIOVASCULAR EFFECTS OF PAF......Page 306 SUMMARY......Page 309 REFERENCES......Page 311 MATERIALS AND METHODS......Page 313 RESULTS......Page 314 DISCUSSION......Page 315 REFERENCES......Page 316 MATERIALS AND METHODS......Page 318 RESULTS......Page 319 DISCUSSION......Page 320 REFERENCES......Page 321 MATERIALS AND METHODS......Page 323 RESULTS......Page 324 REFERENCES......Page 325 EFFECT OF PAF ON AIRWAYS......Page 326 CONCLUSIONS......Page 327 REFERENCES......Page 328 ALLERGEN-INDUCED BRONCHIAL HYPERRESPONSIVENESS......Page 329 REFERENCES......Page 330 MATERIALS AND METHODS......Page 332 DISCUSSION......Page 333 REFERENCES......Page 335 MATERIALS AND METHODS......Page 336 RESULTS......Page 337 DISCUSSION......Page 338 REFERENCES......Page 340 MATERIALS AND METHODS......Page 341 RESULTS......Page 342 ACKNOWLEDGMENTS......Page 344 REFERENCES......Page 345 MATERIALS AND METHODS......Page 346 RESULTS......Page 347 DISCUSSION......Page 348 REFERENCES......Page 349 MATERIALS AND METHODS......Page 350 RESULTS......Page 351 DISCUSSION......Page 352 REFERENCES......Page 353 MATERIALS AND METHODS......Page 354 RESULTS......Page 355 DISCUSSION......Page 356 REFERENCES......Page 358 PAF PRODUCTION BY THE KIDNEY......Page 359 A ROLE FOR PAF IN EXPERIMENTAL PROLIFERATIVE, LEUKOCYTE-DEPENDENT GLOMERULONEPHRITIS......Page 360 PAF IN THE PATHOGENESIS OF NON-PROLIFERATIVE EXPERIMENTAL NEPHROTIC SYNDROME......Page 361 REFERENCES......Page 363 MATERIALS AND METHODS......Page 365 RESULTS......Page 366 DISCUSSION......Page 367 REFERENCES......Page 368 MATERIALS AND METHODS......Page 369 DISCUSSION......Page 370 REFERENCES......Page 372 MATERIALS AND METHODS......Page 373 RESULTS......Page 374 DISCUSSION......Page 375 REFERENCES......Page 376 MATERIAL AND METHODS......Page 378 DISCUSSION......Page 379 REFERENCES......Page 381 RESULTS AND DISCUSSION......Page 382 REFERENCES......Page 384 REPERFUSION OF THE ISCHEMIC MESENTERIUM......Page 385 EFFECTS OF EXOGENOUS PAF......Page 386 SUMMARY AND CONCLUSIONS......Page 387 REFERENCES......Page 388 THE ROLE OF PAF IN ISCHEMIC BOWEL NECROSIS......Page 389 THE ROLE OF HYPOXIA AND PAF IN INTESTINAL NECROSIS......Page 390 REFERENCES......Page 391 RESULTS AND DISCUSSION......Page 393 REFERENCES......Page 395 MATERIALS AND METHODS......Page 396 RESULTS......Page 398 DISCUSSION......Page 400 REFERENCES......Page 402 RESULTS AND DISCUSSION......Page 403 REFERENCES......Page 404 RESULTS AND DISCUSSION......Page 405 REFERENCES......Page 406 MATERIALS AND METHODS......Page 408 RESULTS AND DISCUSSION......Page 409 REFERENCES......Page 410 CURRENT APPROACHES FOR OXYRADICAL VISUALIZATION......Page 411 IN VIVO OXYRADICAL VISUALIZATION DURING PAF-INDUCED MICROVASCULAR DAMAGE......Page 413 ROLES OF PAF AND LEUKOTRIENE B4 IN GRANULOCYTEMEDIATED OXIDATIVE STRESS DURING MICROVASCULAR DAMAGE......Page 415 REFERENCES......Page 416 LETHAL EFFECT OF ENDOTOXIN AND/OR TUMOR NECROSIS FACTOR TNF......Page 418 CARDIOVASCULAR EFFECTS OF ENDOTOXIN......Page 420 PRIMING OF PAF EFFECTS BY ENDOTOXIN/TNF......Page 421 REFERENCES......Page 422 MATERIALS AND METHODS......Page 423 RESULTS......Page 424 REFERENCES......Page 428 MATERIALS AND METHODS......Page 430 RESULTS......Page 431 DISCUSSION......Page 432 REFERENCES......Page 433 MATERIALS AND METHODS......Page 435 RESULTS......Page 436 DISCUSSION......Page 437 REFERENCES......Page 439 MATERIALS AND METHODS......Page 440 RESULTS......Page 441 DISCUSSION......Page 442 REFERENCES......Page 443 MATERIALS AND METHODS......Page 445 RESULTS......Page 446 REFERENCES......Page 447 MATERIALS AND METHODS......Page 449 RESULTS......Page 450 DISCUSSION......Page 451 REFERENCES......Page 452 MATERIALS AND METHODS......Page 453 RESULTS......Page 454 REFERENCES......Page 455 MATERIALS AND METHODS......Page 457 RESULTS......Page 458 DISCUSSION......Page 459 REFERENCES......Page 460 Hexadecylphosphocholine: Preclinical and the First Clinical Results of a New Antitumor Drug......Page 461 ALKYL PHOSPHOCHOLINES: A NEW CLASS OF ANTITUMORAL AGENTS......Page 462 REFERENCES......Page 465 MATERIALS AND METHODS......Page 467 RESULTS......Page 469 DISCUSSION......Page 470 REFERENCES......Page 471 MATERIALS AND METHODS......Page 473 RESULTS AND DISCUSSION......Page 476 REFERENCES......Page 479 MATERIALS AND METHODS......Page 480 RESULTS......Page 482 DISCUSSION......Page 483 REFERENCES......Page 485 MATERIALS AND METHODS......Page 486 RESULTS......Page 488 DISCUSSION......Page 492 REFERENCES......Page 493 MATERIALS AND METHODS......Page 494 RESULTS......Page 495 REFERENCES......Page 497