Process Scale Liquid Chromatography

This book provides the industrial chromatographer and production scientist with a comprehensive account of process scale liquid chromatography. The basic theory is presented, guiding the reader through system design, simulation and modelling techniques, giving due consideration to economic aspects, as well as safety and regulatory factors. A thorough, up-to-date survey of current techniques and media does stress their advantages and limitations in such a way as to faciliate their application to real-life problems. In view of rapid rate of development in industrial chromatography one chapter provides an assessment of future developments. The chapters are written by acknowledged experts from Europe and the United States. Cover......Page 1 Process Scale Liquid Chromatography......Page 4 Preface......Page 8 Contents......Page 10 Contributors......Page 16 1. Chromatography Systems - Design and Control......Page 20 2. The Practical Application of Theory in Preparative Liquid Chromatography......Page 52 3. Alternative Modes of Operation of Chromatography Columns in the Process Situation......Page 90 4. Process Scale Size Exclusion Chromatography......Page 100 5. Polymers and their Application in Liquid Chromatography......Page 118 6. Biochemical Applications of Process-ScaleIon-Exchange Liquid Chromatography......Page 150 7. Instrumental Design and Separation in Large Scale Industrial Supercritical Fluid Chromatography......Page 172 8. Scaling-up of Supercritical Fluid Chromatography to Large-Scale Applications......Page 182 9. Affinity Chromatography and its Applications in Large-Scale Separations......Page 212 Index......Page 234

This book provides the industrial chromatographer and production scientist with a comprehensive account of process scale liquid chromatography. The basic theory is presented, guiding the reader through system design, simulation and modelling techniques, giving due consideration to economic aspects, as well as safety and regulatory factors. A thorough, up-to-date survey of current techniques and media does stress their advantages and limitations in such a way as to faciliate their application to real-life problems. In view of rapid rate of development in industrial chromatography one chapter provides an assessment of future developments. The chapters are written by acknowledged experts from Europe and the United States.

Aimed at chromatographers, chemical engineers, pharmaceutical engineers and analytical chemists, this text covers process scale chromatography.