This volume contains papers that were presented and discussed at The 1996 Interna tional Symposium on Programmed Cell Death, which was held in the Shanghai Science Center of the Chinese Academy of Sciences on September 8-12, 1996. Apoptosis has attracted great attention in the past several years. This is reflected in part by the exponential increase in the number of papers published on the subject. While several major scientific conferences have been held in recent years, this meeting repre sents the first major international scientific meeting on programmed cell death held in Asia, where fast economic growth promises a bright future for both basic and applied re search in biomedical sciences. We organized the meeting with the belief that such a gath ering would foster a closer interaction between scientists from the West and those in Asia. Research on programmed cell death has expanded so extensively that no one meet ing can cover all the important subjects related to apoptosis. The Shanghai meeting fo cused on several key areas ranging from well-established ones, such as cell death in the immune system, to emerging ones, such as the role ofECM in regUlating cell fate. Specifi cally, the subjects presented and discussed included programmed cell death during devel opment, the regulation and biochemical mechanisms of lymphocyte apoptosis, the involvement of extracellular matrix and its remodeling in programmed cell death, genes that cause or prevent cell death, and the application of apoptosis toward cancer therapy. Front Matter....Pages i-viii How Hormones Regulate Programmed Cell Death during Amphibian Metamorphosis....Pages 1-11 Activation of Matrix Metalloproteinase Genes during Thyroid Hormone-Induced Apoptotic Tissue Remodeling....Pages 13-26 Mechanisms by Which Matrix Metalloproteinases May Influence Apoptosis....Pages 27-34 The Role of Integrin αvβ3 in Cell Survival and Angiogenesis....Pages 35-42 The Role of Granzyme B in Cytotoxic T Lymphocyte Assisted Suicide....Pages 43-50 Caspase Inhibitors as Molecular Probes of Cell Death....Pages 51-62 Cell Volume Regulation, Ions, and Apoptosis....Pages 63-70 Regulation of p53-Dependent Apoptosis in Human Neuroblastoma Cells by Isoquinolines....Pages 71-77 Inducible Fas-Resistance in B Lymphocytes....Pages 79-90 Murder and Suicide....Pages 91-103 Molecular Mechanisms of T Lymphocyte Apoptosis Mediated by CD3....Pages 105-112 Mitogenic Cytokines Promote Apoptosis....Pages 113-124 Molecular Mechanisms of Growth and Death Control of Hematopoietic Cells by Cytokines....Pages 125-133 Genetic Regulation of Apoptosis in the Mouse Thymus....Pages 135-146 Taking Out the Immune Response....Pages 147-158 CD95 (Fas) Ligand....Pages 159-167 Back Matter....Pages 169-171
