Protein Evolution

The flood of information on gene and protein sequences from the genome projects has revolutionzed molecular and evolutionary biology and led to the rapid development of the science called genomics. Reliable prediction of the function of a novel gene/protein requires complex computational analysis of genomic and protein sequence information, which exploit the principles governing the evolution of protein structure and function. This book aims to provide an up-to-date summary of the principles of protein evolution and discusses both the methods available to analyse the evolutionary history of proteins and to predict their structure-function relationships. Protein Evolution is intended for senior undergraduates and graduate students taking courses in protein structure and evolution, as well as bioinformatics. It will also be a useful supplement for students taking wider courses in molecular evolution, as well as a valuable resource for professionals in the area of functional genomics. Clinical Paediatric Endocrinology is now firmly established as the leading international work of reference in the field, covering the pathology of endocrine disorders, their diagnosis and treatment. The book takes a comprehensive approach to the subject and covers the classic hormones as well as growth factors and regulatory peptides, neuroendocrinology, imaging in paediatrics, and the use of diagnostic testing. The clinical descriptions are concise and well supported by photographs, while the sections on investigation and management are extensive.-- New Fourth Edition of a classic text-- 100 pages larger than the previous edition-- Completely reorganised into 10 sections and includes a completely new section on evidence-based paediatric endocrinology "This book aims to provide an up-to-date summary of the principles of protein evolution and discusses both the methods available to analyse the evolutionary history of proteins as well as those for predicting their structure-function relationships. Protein Evolution is intended for senior undergraduates and graduate students taking courses in protein structure and evolution, as well as bioinformatics. It will also be a useful supplement for students taking wider courses in molecular evolution, as well as a valuable resource for professionals in the area of functional genomics."--Jacket