Protein Targeting

Protein Targeting reviews different aspects of protein targeting, including similarities and differences in the pathways involved. The early stages of protein export and secretion in prokaryotes and eukaryotes are examined, along with the targeting of mitochondrial and chloroplast proteins as well as some important differences in the biogenesis of the two organelles. Comprised of nine chapters, this book begins with an overview of terminology and basic principles of protein targeting, focusing on protein traffic in eukaryotic and bacterial cells. The reader is then introduced to the basic principles and techniques of protein targeting, including protein identification and posttranslational modification. Subsequent chapters deal with the early stages in the secretory pathway; later stages in the prokaryotic and eukaryotic secretory pathways; targeting of mitochondrial, chloroplast, and peroxisomal proteins; and targeting of nuclear proteins. The book also discusses endocytosis before concluding with a description of applications of protein targeting. This monograph will be of value to scientists and biotechnologists, as well as to students of cell biology, biochemistry, microbiology, and molecular biology. Content: Front Matter , Page iii Copyright , Page iv Dedication , Page v Preface , Page xi CHAPTER I - An overview of protein targeting , Pages 1-12 CHAPTER II - Basic principles and techniques , Pages 13-44 CHAPTER III - Early stages in the secretory pathway , Pages 45-111 CHAPTER IV - Later stages in the prokaryotic secretory pathway , Pages 112-125 CHAPTER V - Later stages in the eukaryotic secretory pathway , Pages 126-168 CHAPTER VI - The targeting of mitochondrial, chloroplast, and peroxisomal proteins , Pages 169-198 CHAPTER VII - The targeting of nuclear proteins , Pages 199-210 CHAPTER VIII - Endocytosis , Pages 211-228 CHAPTER IX - Applications of protein targeting , Pages 229-240 References , Pages 241-267 Index , Pages 269-279