Provides an n-depth study of the theoretical and engineering principles behind the methods and technologies used to solve problems in experimental and clinical cardiac electrophysiology. Each chapter gives an extensive description of the principles underlying a simple method or technology and illustrates how it can be applied to solve problems in basic research and the clinical environment. Preface......Page 5 Contents......Page 7 Contributors......Page 11 Computer Models of Ion Channels......Page 15 Computation of the Action Potential of a Cardiac Cell......Page 75 Modeling the Impact of Cardiac Tissue Structure on Current Flow and Wavefront Propagation......Page 119 Electrical Stimulation of Cardiac Cells......Page 153 Computer Modeling of De.brillation I: The Role of Cardiac Tissue Structure......Page 213 Computer Modeling of De.brillation II: Why Does the Shock Fail?......Page 249 Theoretical and Practical Considerations for Cardiac Recording and Stimulating Electrodes......Page 273 Impedance Measurements in Cardiac Tissue......Page 303 Electrical Stimulus, Reentry, Fibrillation, and De.brillation: Insights Gained by the Graded Response and Restitution Hypotheses......Page 341 Noncontact Cardiac Mapping......Page 375 Electroanatomical Cardiac Mapping......Page 399 Quantitative Analysis of Complex Rhythms......Page 417 Quantitative Descriptions of Cardiac Arrhythmias......Page 443 Optical Mapping of Microscopic Impulse Propagation......Page 521 The Electrophysiological Substrate for Reentry: Unique Insights from High-Resolution Optical Mapping with Voltage-Sensitive Dyes......Page 569 Optical Mapping of Cardiac Stimulation: Fluorescent Imaging with a Photodiode Array......Page 597 Video Imaging of Fibrillation and De.brillation......Page 637 Index......Page 675 Provides an in-depth study of the theoretical and engineering principles behind the methods and technologies used to solve problems in experimental and clinical cardiac electrophysiology. Each chapter gives an extensive description of the principles underlying a simple method or technology and illustrates how it can be applied to solve problems in Electrical activity in the heart is generated at the molecular level by specialized membrane-spanning proteins that control the movement of ions either by passive electrodiffusion through transmembrane pores (i.e., channels) or translocation across the membrane by carrier proteins (pumps, exchangers, and transporters). Pt. 1. Computer Modeling -- Pt. 2. Electrical Measurements And Mapping -- Pt. 3. Signal Processing -- Pt. 4. Optical Mapping. Edited By Candido Cabo, David S. Rosenbaum. Includes Bibliographical References And Index. Each chapter of this text gives an extensive description of the principles underlying a simple method or technology and illustrates how it can be applied to solve problems in basic research and the environment.
