Receptor binding in drug research

Cover......Page 1 Half Title......Page 2 Series Page......Page 3 Title Page......Page 4 Copyright Page......Page 5 Dedication Page......Page 6 Series Introduction......Page 10 Foreword......Page 12 Preface......Page 14 Contents......Page 16 Contributors......Page 20 Part I Analysis and Interpretation of Receptor Screening Data......Page 26 1 Receptor Binding Methodology and Analysis......Page 28 2 Computer Analysis of Binding Data......Page 56 Part II Receptor Screening Applied to Specific Therapeutic Areas......Page 76 3 Benzodiazepines and Nonbenzodiazepines......Page 78 4 Enhancers of Benzodiazepine Binding......Page 102 5 Convulsant and Anticonvulsant Drug Receptor Binding......Page 118 6 Neuroleptic Receptor Binding in Drug Research......Page 148 7 Receptor Binding and Atypical Antidepressant Drug Discovery......Page 176 8 Central Recognition Sites for Psychomotor Stimulants: Methylphenidate and Amphetamine......Page 192 9 Opiate Receptor Binding in Drug Research......Page 208 Part III Receptor Interactions with Implications in Multiple Therapeutic Areas......Page 228 10 Molecular Heterogeneity of Leukotriene Receptors......Page 230 11 Purinergic Receptors in Mammalian Tissue......Page 260 12 New Routine Methodology to Study Steroid Hormone Binding Sites in Heterogeneous Tissues......Page 286 13 Application of Ligand Binding to the Development of New Calcium Antagonists and Activators......Page 308 14 Muscarinic Cholinergic Receptor Binding......Page 322 Part IV Receptor Applications to Peptides, Grow th Factors, and Endogenous Ligands......Page 346 15 Interferon Receptors: Progress and Prospects......Page 348 16 The Platelet-Derived Growth Factor Receptor......Page 362 17 Receptor Screening Assays for Insulin and Other Growth Factors......Page 376 18 Cholecystokinin Receptor Binding: Its Use in Drug Research and Development......Page 404 19 Using Radioreceptor Binding Assays to Identify Endogenous Ligands......Page 418 Part V In Vivo and In Vitro Receptor Methodologies for Use in Drug Discovery and Characterization......Page 432 20 In Vivo Receptor Modifications as a Measure of Antidepressant Potential......Page 434 21 Antidepressant Interactions with Neurotransmitter Receptors in Vitro: Prediction of Potential Side Effects......Page 454 22 Altered Responsiveness of the Noradrenergic-Coupled Adenylate Cyclase System in Brain......Page 474 23 Quantitative Autoradiography in Drug Research: Tricyclic Antidepressants......Page 502 24 Characterization of Agonist and Antagonist Interactions at the Benzodiazepine Receptor......Page 512 25 Receptor Binding Assays for Muscarinic Cholinergic Agonists......Page 522 Index......Page 536 This book describes the applications of receptor techniques in many different areas in addition to conventional drug and neurotransmitter binding sites. It reviews humoral modulators such as a leukotrienes, interferon, platelet-derived growth factor, and novel endogenous ligands.