Solid State Characterization of Pharmaceuticals

The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: Physical properties and processes Thermodynamics Intellectual guidance X-ray diffraction Spectroscopy Microscopy Particle sizing Mechanical properties Vapour sorption Thermal analysis & Calorimetry Polymorph prediction Form selection Annotation The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: Physical properties and processes Thermodynamics Intellectual guidance X-ray diffraction Spectroscopy Microscopy Particle sizing Mechanical properties Vapour sorption Thermal analysis & Calorimetry Polymorph prediction Form selection fmatter.pdf......Page 1 ch1.pdf......Page 19 ch2.pdf......Page 53 ch3.pdf......Page 89 ch4.pdf......Page 153 ch5.pdf......Page 205 ch6.pdf......Page 225 ch7.pdf......Page 250 ch8.pdf......Page 261 ch9.pdf......Page 302 ch10.pdf......Page 371 ch11.pdf......Page 401 ch12.pdf......Page 440 ch13.pdf......Page 464 ch14.pdf......Page 485 index.pdf......Page 504 Solid form selection is a critical part of the development of a pharmaceutical compound. Owing to different crystal structures, polymorphic forms of a compound have different physical and chemical properties, which can affect the biopharmaceutical properties of a pharmaceutical compound.