Stem Cell and Gene Therapy for Cardiovascular Disease

__Stem Cell and Gene Therapy for Cardiovascular Disease__ is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. * Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials * Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis * Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI * Covers the prevailing opinions on how to harness the body’s natural repair mechanisms * Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals Content: Front-matter,Copyright,List of Contributors,Preface,Regenerative Medicine and the Cardiovascular System: A Good Start*Entitled to full textPart I: Stem CellsChapter 1 - Introduction and Overview of Stem Cells, Pages 3-11, Leslie W. Miller, Emerson C. Perin Chapter 2 - Pathological Assessment of Experimental Models of Stem Cell and Other Regenerative Therapies, Pages 13-23, Deborah Vela, L. Maximilian Buja Chapter 3 - Large Animal Models for Cardiac Cell Therapy, Pages 25-36, Elton Migliati Chapter 4 - Role of Paracrine Mechanisms, Pages 39-48, Conrad P. Hodgkinson, José A. Gomez, Akshay Bareja, Victor J. Dzau Chapter 5 - Impact of Telomere Shortening with Age in Stem Cell Therapy: New Strategies to Increase Telomere Length, Pages 49-58, Nathalie Nguyen, Nirmala Hariharan, Mark A. Sussman Chapter 6 - Peripheral Arterial Disease, Pages 61-78, Douglas W. Losordo, Amy Chung, Zhen Chen, John P. Cooke Chapter 7 - Cell Therapy for Refractory Angina, Pages 79-90, Sandeep K. Krishnan, E. Marc Jolicoeur, Timothy D. Henry Chapter 8A - Stem Cell Therapy for Acute Myocardial Infarction: The European Experience, Pages 91-99, Leslie W. Miller Chapter 8B - Acute Myocardial Infarction: The United States Experience, Pages 101-110, Jay H. Traverse Chapter 9 - Autologous Bone Marrow Cells for Chronic Ischemic Heart Failure, Pages 111-116, Amir Gahremanpour, Emerson C. Perin Chapter 10 - Adipose-Derived Stem Cells, Pages 119-135, W. Gathier, Z. Türktaş, H.J. Duckers Chapter 11 - Mesenchymal Stem Cells, Pages 139-150, Amit N. Patel, Courtney E. Bartlett, Thomas E. Ichim Chapter 12 - Allogeneic versus Autologous Source: Comparative Effects, Pages 151-168, Sabrina Taldone, Ivonne Hernandez Schulman, Wayne Balkan, Joshua M. Hare Chapter 13 - Allogeneic Alternatives to Autologous Bone Marrow: The MSC Clinical Trials of Acute MI with MSCs, Pages 169-179, Angela Castellanos, Wayne Balkan, Ivonne Hernandez Schulman, Joshua M. Hare Chapter 14 - Allogeneic Alternatives to Autologous Bone Marrow: The MSC Combined Cell Strategies, Pages 181-192, Wayne Balkan, Ivonne Hernandez Schulman, Joshua M. Hare Chapter 15 - Clinical Trials to Date with MSCs: Heart Failure, Pages 193-197, Luis Felipe Silva Smidt, Emerson C. Perin Chapter 16 - Therapy with c-kitPOS Cardiac Stem Cells for Ischemic Cardiomyopathy, Pages 201-215, Kyung U. Hong, Roberto Bolli Chapter 17 - Cardiosphere-Derived Cells, Pages 217-222, Rachel Ruckdeschel Smith Chapter 18 - Cardiovascular Regenerative Cell Therapy Using Umbilical Cord and Endometrial Cells, Pages 225-231, Amit N. Patel, Thomas E. Ichim Chapter 19 - Cardiopoietic Stem Cells for Heart Failure Therapy, Pages 235-241, Atta Behfar, Andre Terzic Chapter 20 - Transformation to Inducible Pluripotent Stem Cells, Pages 243-265, Kazuki Kodo, Sang-Ging Ong, Joseph C. Wu Chapter 21 - Multipotent Adult Progenitor Cells (MAPCs) for Cardiovascular and Neurologic Diseases, Pages 267-275, Valerie D. Roobrouck, Philip R. Roelandt, Catherine M. Verfaillie Chapter 22 - Intravenous, Intracoronary, Transendocardial, and Advential Delivery, Pages 279-287, Emerson C. Perin Chapter 23 - Retrograde Coronary Sinus Delivery for Cardiac Cell Therapy, Pages 289-293, Amit N. Patel Chapter 24 - Current Perspectives on Methods for Administering Human Pluripotent Stem Cell-Derived Cells for Myocardial Repair, Pages 297-308, Jun Fujita, Keiichi Fukuda, Leslie W. Miller, Jianyi (Jay) Zhang Chapter 25 - Acellular Injectable Biomaterials for Treating Cardiovascular Disease, Pages 309-325, Roberto Gaetani, Jessica Ungerleider, Karen L. Christman Chapter 26 - Scaffold-Based Cell Delivery for Cardiac Repair, Pages 327-339, Lisle Blackbourn, Eric G. Schmuck, Amish N. Raval Chapter 27 - Biomaterial: Alginate, Pages 341-348, David S. Lee, Randall J. Lee Chapter 28 - Organogenesis, Pages 349-373, Andrea S. Gobin, Doris A. Taylor, Eric Chau, Luiz C. Sampaio Chapter 29 - Gene Therapy for Cardiovascular Diseases, Pages 377-387, Thomas Weber, Lior Zangi, Roger J. Hajjar Chapter 30 - SERCA2a Gene Therapy for Heart Failure, Pages 389-400, Antoine H. Chaanine, Alex Yaroshinsky, Roger J. Hajjar Chapter 31 - SDF-1 for Cardiac Repair, Pages 401-407, Deephak Swaminath, Brittany M. Penn, Marc S. Penn Chapter 32 - Gene Therapy in Critical Limb Ischemia, Pages 409-416, Robert M. Cole, Alan T. Hirsch, Timothy D. Henry Chapter 33 - Use of Gene Modified Stem Cells for Acute Myocardial Infarction, Pages 417-432, Michael J.B. Kutryk, Duncan J. Stewart Chapter 34 - The History and Future of the Cardiovascular Cell Therapy Research Network, Pages 435-443, Robert D. Simari, Ray F. Ebert, Lem Moyé Chapter 35 - Signature of Responders—Lessons from Clinical Samples, Pages 445-460, Micheline Resende, Luiz C. Sampaio, Aaron Orozco, Doris A. Taylor Chapter 36 - Adjunctive Therapies with LVADs: Combining Biological and Mechanical Regenerative Therapies, Pages 461-469, Deborah D. Ascheim, William Hiesinger, Annetine C. Gelijns, Y. Joseph Woo, Kimberly N. Hong Chapter 37 - Trials in Non-ischemic Heart Failure, Pages 471-483, Bojan Vrtovec Chapter 38 - New Strategies to Enhance Stem Cell Homing for Tissue Repair, Pages 485-496, Leslie W. Miller Chapter 39 - Cell Therapy in Ischemic Stroke, Pages 497-507, Vivek Misra, Sean I. Savitz Index, Pages 509-515

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic.

As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials.

Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic.

• Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials
• Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis
• Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI
• Covers the prevailing opinions on how to harness the body’s natural repair mechanisms
• Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals