Stem Cells in the Nervous System: Functional and Clinical Implications (Research and Perspectives in Neurosciences)

After 40 years of research, scientists have confirmed that persistent neurogenesis occurs in the adult mammalian brain. The obvious next question is: "Are the newly generated neurons functional?" If so, "What are the functions of these new neurons?" This volume intends to clarify both questions by providing the latest data available. Front Matter....Pages I-XII Neurogenesis in adult brain: understanding its mechanism and regulation....Pages 1-23 The Logic of Neural Cell Lineage Restriction: Neuropoiesis Revisited....Pages 25-41 Astrocytic nature of adult neural stem cells in vivo....Pages 43-56 What is the Functional Role of New Neurons in the Adult Dentate Gyrus?....Pages 57-65 Do Forebrain Neural Stem Cells Have a Role in Mammalian Olfactory Behavior?....Pages 67-82 Converting ES Cell into Neurons....Pages 83-93 Stem Cell Infidelity....Pages 95-107 The Importance of CNS Stem Cells in Development and Disease....Pages 109-116 In Vivo Properties of In Vitro-Propagated Neural Stem Cells After Transplantation to the Neonatal and Adult Rat Brain....Pages 117-138 Neurogenesis in Stroke and Epilepsy....Pages 139-146 The Incorrect Use of Transcription Factors: A Key to Your (STEM) Cells?....Pages 147-156 Leukemia and Leukemic Stem Cells....Pages 157-182 Back Matter....Pages 183-184