Stress Response in Pathogenic Bacteria. 19

Contents......Page 5 Contributors......Page 7 Preface......Page 9 PART 1: OXIDATIVE AND NITROSATIVE STRESS......Page 11 1 Oxidative and Nitrosative Stress Defence Systems in Escherichia coli and Pseudomonas aeruginosa: A Model Organism of Study Versus a Human Opportunistic Pathogen......Page 13 2 Coordinated Regulation of Stress and Virulence Adaptations in Stages of Haemophilus Pathogenesis......Page 43 3 Nitric Oxide Stress in Escherichia coli and Salmonella......Page 58 4 Nitric Oxide and Gram-positive Pathogens: Host Triggers and Bacterial Defence Mechanisms......Page 78 PART 2: NOVEL GENE REGULATION IN RESPONSE TO HOST DEFENCES......Page 101 5 Novel Regulation in Response to Host-generated Stresses: The MerR Family of Regulators in Pathogenic Bacteria......Page 103 6 Stress Responses in the Pathogenic Neisseria: Overlapping Regulons and sRNA Regulation......Page 125 PART 3: ACID STRESS, PH CONTROL AND SURVIVAL IN THE HUMAN HOST......Page 143 7 Acid Survival Mechanisms of Bacterial Pathogens of the Digestive Tract......Page 145 8 Urease and the Bacterial Acid Stress Response......Page 177 PART 4: NUTRIENT STRESS......Page 193 9 Secretion Systems and Metabolism in the Pathogenic Yersiniae......Page 195 10 Response of Neisseria gonorrhoeae to Oxygen Limitation and Excess......Page 231 PART 5: METAL LONS AND PATHOGENIC BACTERLA......Page 253 11 Copper and Zinc Stress in Bacteria......Page 255 12 Metal Ion Sensing in Mycobacterium tuberculosis......Page 276 13 Salmonella and the Host in the Battle for Iron......Page 293 A......Page 307 D......Page 308 G......Page 309 I......Page 310 M......Page 311 O......Page 312 Q......Page 313 S......Page 314 T......Page 315 Z......Page 316 The ability of pathogenic bacteria to adapt to various chemical, biochemical and physical conditions within the human host and their ability to respond to stresses generated in these environments is a central feature of infectious diseases and the outcome of bacterial infection. This book covers the key aspects of this rapidly developing field, including the generation of stresses by the host immune system, bacterial response to reactive chemicals, and adaptation to environmental conditions of anatomical niches such as the gut, mouth and urogenital tract. It also addresses the increasing importance of different metal ions in the pathogenesis and survival of specific bacteria. With chapters by active research experts in the field, the book provides a comprehensive outline of the current understanding of this field, the latest developments and where future research is likely to be directed. It is suitable for researchers in microbiology, immunology, biochemistry and bacterial physiology