Systemic sclerosis : basic and translational research

"This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists." -- Font no determinada Front Matter....Pages i-viii Fibrosis: Overview....Pages 1-20 Autoimmunity in Systemic Sclerosis: Overview....Pages 21-37 Endothelial Progenitor Cells....Pages 39-56 Animal Models of Systemic Sclerosis....Pages 57-79 Genetics of Systemic Sclerosis....Pages 81-92 Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis....Pages 93-102 Interleukin-6 in the Pathogenesis of Systemic Sclerosis....Pages 103-115 Epigenetics....Pages 117-136 Transforming Growth Factor-ß and Connective Tissue Growth Factor....Pages 137-153 Endothelin....Pages 155-171 The Role of B Cells in Systemic Sclerosis....Pages 173-185 Fli1....Pages 187-209 Biomarker....Pages 211-229 Autoantibodies in Systemic Sclerosis....Pages 231-247