Systems Metabolic Engineering

Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field. Front Matter....Pages i-xii Genome-Scale Network Modeling....Pages 1-23 Kinetic Modeling of Metabolic Networks....Pages 25-55 Design of Superior Cell Factories Based on Systems Wide Omics Analysis....Pages 57-81 Technologies for Biosystems Engineering....Pages 83-115 Systems Metabolic Engineering of Escherichia coli for Chemicals, Materials, Biofuels, and Pharmaceuticals....Pages 117-149 Systems Metabolic Engineering of Corynebacterium glutamicum for Biobased Production of Chemicals, Materials and Fuels....Pages 151-191 Towards a Synthetic Biology of the Stress-Response and the Tolerance Phenotype: Systems Understanding and Engineering of the Clostridium acetobutylicum Stress-Response and Tolerance to Toxic Metabolites....Pages 193-219 Model-Based Design of Superior Cell Factory: An Illustrative Example of Penicillium chrysogenum ....Pages 221-270 Bridging Omics Technologies with Synthetic Biology in Yeast Industrial Biotechnology....Pages 271-327 Design of Superior Cell Factories for a Sustainable Biorefinery By Synthetic Bioengineering....Pages 329-348 Systems-Level Analysis of Cancer Metabolism....Pages 349-381 Back Matter....Pages 383-387 Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. ¡ Integrating systems biology and biotechnology with new concepts from synthetic biology, it enables the global analysis and engineering of microorganisms - and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story - from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundament to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter into this exiting field