This edition discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels. In addition to a comprehensive discussion of various autoimmune diseases and organ systems, the editors also cover the role of autoimmunity in cancer, AIDS, and aging. Content: Front Matter , Page iii Copyright , Page iv Contributors , Pages xiii-xv Foreword , Pages xvii-xxi Editors' Tribute to Sir Macfarlane Burnet , Page xxii Preface , Page xxiii Introduction , Pages xxv-xxxvi CHAPTER 1 - Genetic Predisposition to Autoimmune Diseases , Pages 1-27 CHAPTER 2 - Systemic Lupus Erythematosus , Pages 29-57 CHAPTER 3 - Autoimmune Aspects of Rheumatoid Arthritis , Pages 59-79 CHAPTER 4 - Mixed Connective Tissue Disease , Pages 81-118 CHAPTER 5 - Scleroderma , Pages 119-143 CHAPTER 6 - Sjögren's Syndrome , Pages 145-159 CHAPTER 7 - Autoimmune Thyroid Disease , Pages 161-199 CHAPTER 8 - Adrenal Autoimmunity and Autoimmune Polyglandular Syndromes , Pages 201-225 CHAPTER 9 - Immunology of Insulin-Dependent Diabetes , Pages 227-242 CHAPTER 10 - Pernicious Anemia and Gastric Atrophy , Pages 243-266 CHAPTER 11 - Inflammatory Bowel Diseases , Pages 267-289 CHAPTER 12 - Autoimmune Diseases of the Liver: Chronic Active Hepatitis and Primary Biliary Cirrhosis , Pages 291-337 CHAPTER 13 - Autoimmune Kidney Diseases , Pages 339-370 CHAPTER 14 - Ocular Diseases of Presumed Autoimmune Origin , Pages 371-398 CHAPTER 15 - Multiple Sclerosis, Allied Central Nervous System Diseases, and Immune-Mediated Neuropathies , Pages 399-427 CHAPTER 16 - Immunological Influences in Cardiovascular Disease , Pages 429-441 CHAPTER 17 - Autoimmune Cutaneous Diseases , Pages 443-467 CHAPTER 18 - Autoimmune Hemolytic Anemia , Pages 469-491 CHAPTER 19 - Idiopathic Thrombocytopenic Purpura , Pages 493-521 CHAPTER 20 - Autoimmune Neutropenia , Pages 523-536 CHAPTER 21 - Sperm and Testicular Autoimmunity , Pages 537-590 CHAPTER 22 - Autoimmune Diseases of Muscle: Myasthenia Gravis and Myositis , Pages 591-615 CHAPTER 23 - Antireceptor Antibodies , Pages 617-668 CHAPTER 24 - Sensitivity and Specificity of Autoantibody Testing , Pages 669-693 CHAPTER 25 - Autoimmunity of the Future , Pages 695-706 Index , Pages 707-727 The Autoimmune Diseases is composed of 25 chapters dealing with different aspects of some specific autoimmune diseases. The book begins with the elucidation of the genetic predisposition to autoimmune diseases. Subsequent chapters explore numerous kinds of autoimmune diseases. Other chapters describe the antireceptor antibodies and the sensitivity and specificity of autoantibody testing. This book is designed to provide a deeper understanding of this increasingly important field of medical science for physicians and investigators involved in the diagnosis, treatment, or research of autoimmune diseases. Discusses autoimmune disease in humans (as opposed to the disease itself). This book discusses the biological basis of disease at the molecular, genetic, cellular and epidemiologic levels. It also describes the clinical problems of diagnosis, prognosis and treatment.
